S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → S-adenosyl-L-homocysteine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + H⁺

7-deoxyloganetate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 7-deoxyloganetin

S-adenosyl-L-methionine + phenazine-1-carboxylate → S-adenosyl-L-homocysteine + 5-methylphenazine-1-carboxylate

S-adenosyl-L-methionine + (S)-norreticuline → S-adenosyl-L-homocysteine + H⁺ + (S)-norlaudanine

phenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + anisole + H⁺

S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin → S-adenosyl-L-homocysteine + 8-demethyl-8-(methylamino)riboflavin + H⁺

3-hydroxy-L-kynurenine + S-adenosyl-L-methionine → 3-hydroxy-4-methyl-L-kynurenine + S-adenosyl-L-homocysteine + H⁺

2 NADPH + palmatine + S-adenosyl-L-methionine → 2 NADP⁺ + S-adenosyl-L-homocysteine + corydaline

N-dimethylethanolamine phosphate + S-adenosyl-L-methionine → phosphocholine + S-adenosyl-L-homocysteine + H⁺

(R)-reticuline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + (R)-laudanine

S-adenosyl-L-methionine + L-olivosyl-oleandolide → S-adenosyl-L-homocysteine + H⁺ + L-oleandrosyl-oleandolide

S-adenosyl-L-methionine + isoliquiritigenin → S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin + H⁺

2 S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-α-D-forosamine

S-adenosyl-L-methionine + daphnetin → S-adenosyl-L-homocysteine + H⁺ + 7-hydroxy-8-methoxycoumarin

S-adenosyl-L-methionine + 13-deoxycarminomycin → S-adenosyl-L-homocysteine + H⁺ + 13-deoxydaunorubicin

S-adenosyl-L-methionine + DIMBOA-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + HMDBOA-glucoside

S-adenosyl-L-methionine + (+)-norpseudoephedrine → 2 H⁺ + S-adenosyl-L-homocysteine + pseudoephedrine

S-adenosyl-L-methionine + 2,4',7-trihydroxyisoflavanone → S-adenosyl-L-homocysteine + (2R,3S)-2,7-dihydroxy-4'-methoxyisoflavanone + H⁺

S-adenosyl-L-methionine + scutellarein 7-methyl ether → S-adenosyl-L-homocysteine + H⁺ + ladanein

2 NADPH + 2 S-adenosyl-L-methionine + 2 oxygen + 4-methylsalicylate + H⁺ + all-trans-hexaprenyl diphosphate → 2 H₂O + 2 S-adenosyl-L-homocysteine + 2 NADP⁺ + 3-demethylubiquinol-6 + diphosphate + CO₂

S-adenosyl-L-methionine + 4-demethyl-7-(3-amino-3-carboxypropyl)wyosine → S-adenosyl-L-homocysteine + H⁺ + 7-[(3S)-(3-amino-3-carboxypropyl)-4-methyl]wyosine

S-adenosyl-L-methionine + a reduced electron donor + cobalt-factor III → an oxidized electron donor + S-adenosyl-L-homocysteine + cobalt-precorrin-4

S-adenosyl-L-methionine + (indol-3-yl)acetate → S-adenosyl-L-homocysteine + methyl (indol-3-yl)acetate

S-adenosyl-L-methionine + C30 botryococcene → S-adenosyl-L-homocysteine + showacene + H⁺

S-adenosyl-L-methionine + 3-hydroxy-D-kynurenine → S-adenosyl-L-homocysteine + H⁺ + 3-hydroxy-4-methyl-D-kynurenine

S-adenosyl-L-methionine + L-tryptophan → S-adenosyl-L-homocysteine + H⁺ + 2-methyl-L-tryptophan

N-demethylvindolidine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + vindolidine + H⁺

S-adenosyl-L-methionine + furaneol (enol form) → S-adenosyl-L-homocysteine + H⁺ + mesifurane (enol form)

S-adenosyl-L-methionine + 3,7,3'-trimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',5'-tetramethylmyricetin

5-hydroxy-feruloyl-CoA + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + sinapoyl-CoA

S-adenosyl-L-methionine + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 2'-hydroxy 3,6,7,3',4'-pentamethylquercetagetin

S-adenosyl-L-methionine + laricitrin → syringetin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 3-demethylubiquinol-10 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-10

3-demethylubiquinol-6 + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-6

orcinol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-methoxy-5-hydroxytoluene + H⁺

phloroglucinol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dihydroxyanisole + H⁺

kaempferide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,4'-dimethylkaempferol

S-adenosyl-L-methionine + N-desmethyl-gliotoxin → S-adenosyl-L-homocysteine + H⁺ + gliotoxin

3 S-adenosyl-L-methionine + glycine → 3 S-adenosyl-L-homocysteine + 3 H⁺ + glycine betaine

3 S-adenosyl-L-methionine + (S)-norlaudanosoline → 3 S-adenosyl-L-homocysteine + 3 H⁺ + (S)-reticuline

S-adenosyl-L-methionine + cobalt-precorrin-5B → 2 H⁺ + S-adenosyl-L-homocysteine + cobalt-precorrin-6A

S-adenosyl-L-methionine + methanethiol → S-adenosyl-L-homocysteine + H⁺ + dimethyl sulfide

S-adenosyl-L-methionine + 8-ethyl-12-methyl-3-vinylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 8,12-diethyl-3-vinylbacteriochlorophyllide d + H⁺

S-adenosyl-L-methionine + cobalt-precorrin-7 → S-adenosyl-L-homocysteine + cobalt-precorrin-8

2 S-adenosyl-L-methionine + a reduced electron donor + cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + cephaeline → S-adenosyl-L-homocysteine + H⁺ + emetine

S-adenosyl-L-methionine + N-demethyllincomycin → S-adenosyl-L-homocysteine + H⁺ + lincomycin A

S-adenosyl-L-methionine + 4'-O-demethylrebeccamycin → S-adenosyl-L-homocysteine + H⁺ + rebeccamycin

S-adenosyl-L-methionine + 9-demethylpremithramycin A3 → S-adenosyl-L-homocysteine + H⁺ + premithramycin A3

S-adenosyl-L-methionine + Mg-protoporphyrin → S-adenosyl-L-homocysteine + magnesium-protoporphyrin IX 13-monomethyl ester

S-adenosyl-L-methionine + genistein → S-adenosyl-L-homocysteine + H⁺ + biochanin-A

S-adenosyl-L-methionine + 24-methylidenelophenol → S-adenosyl-L-homocysteine + 24-ethylidenelophenol + H⁺

S-adenosyl-L-methionine + 2-nonaprenyl-6-methoxy-1,4-benzoquinone → S-adenosyl-L-homocysteine + 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone

2 S-adenosyl-L-methionine + norbaeocystin → 2 S-adenosyl-L-homocysteine + 2 H⁺ + psilocybin

2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-α-D-glucopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-α-D-mycaminose

S-adenosyl-L-methionine + 3',4'-dimethylmyricetin → S-adenosyl-L-homocysteine + 3',4',5'-trimethylmyricetin

S-adenosyl-L-methionine + isoscopoletin → S-adenosyl-L-homocysteine + H⁺ + scoparone

S-adenosyl-L-methionine + tryptamine → S-adenosyl-L-homocysteine + N-methyltryptamine + H⁺

S-adenosyl-L-methionine + glutathione → S-adenosyl-L-homocysteine + S-methylglutathione + H⁺

S-adenosyl-L-methionine + 3',4',5'-trimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,3',4',5'-tetramethylmyricetin

S-adenosyl-L-methionine + 8-demethyl-8-α-L-rhamnosyl-tetracenomycin C → S-adenosyl-L-homocysteine + H⁺ + 8-demethyl-8-(2-O-methyl-α-L-rhamnosyl)-tetracenomycin C

demethylmacrocin + S-adenosyl-L-methionine → macrocin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + lathosterol → 4α-methyl-5α-cholest-7-en-3β-ol + S-adenosyl-L-homocysteine + H⁺

(S)-norcoclaurine + S-adenosyl-L-methionine → (S)-coclaurine + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + N1-hydroxy-roquefortine C → S-adenosyl-L-homocysteine + H⁺ + roquefortine F

S-adenosyl-L-methionine + (S)-norlaudanine → S-adenosyl-L-homocysteine + H⁺ + (S)-tetrahydropapaverine

S-adenosyl-L-methionine + 10-hydroxydihydrosanguinarine → S-adenosyl-L-homocysteine + dihydrochelirubine + H⁺

N-methylethanolamine phosphate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-dimethylethanolamine phosphate + H⁺

S-adenosyl-L-methionine + geranyl diphosphate → S-adenosyl-L-homocysteine + (E)-2-methylgeranyl diphosphate + H⁺

S-adenosyl-L-methionine + norbikaverin → S-adenosyl-L-homocysteine + bikaverin

S-adenosyl-L-methionine + (-)-thujaplicatin → S-adenosyl-L-homocysteine + 5-O-methylthujaplicatin + H⁺

S-adenosyl-L-methionine + β-peltatin → S-adenosyl-L-homocysteine + β-peltatin-A methyl ether + H⁺

psilocybin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + aeruginascin + H⁺

S-adenosyl-L-methionine + 12-ethyl-8-propylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-propylbacteriochlorophyllide c + H⁺

hydroxyspirilloxanthin + S-adenosyl-L-methionine → spirilloxanthin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + demethylmenaquinol-10 → S-adenosyl-L-homocysteine + menaquinol-10 + H⁺

secologanate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + secologanin

S-adenosyl-L-methionine + 5-O-methylthujaplicatin → S-adenosyl-L-homocysteine + O4,O5--dimethylthujaplicatin + H⁺

S-adenosyl-L-methionine + δ-tocotrienol → S-adenosyl-L-homocysteine + H⁺ + β-tocotrienol

S-adenosyl-L-methionine + quercetin → S-adenosyl-L-homocysteine + rhamnetin

S-adenosyl-L-methionine + 3,7,4'-trimethylquercetin 2'-O-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',4'-tetramethylquercetin 2'-O-β-D-glucoside

dihydrosterigmatocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 8-O-methyldihydrosterigmatocystin + H⁺

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + sequoyitol

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + D-ononitol

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + L-bornesitol

myo-inositol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + D-bornesitol

2 S-adenosyl-L-methionine + sarcosine → 2 S-adenosyl-L-homocysteine + 2 H⁺ + glycine betaine

S-adenosyl-L-methionine + 1'-hydroxy-1',2'-dihydro-β,ψ-caroten-4'-one → S-adenosyl-L-homocysteine + H⁺ + thiothece-474

bixin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + bixin dimethyl ester

S-adenosyl-L-methionine + trans-anol → S-adenosyl-L-homocysteine + t-anethole + H⁺

S-adenosyl-L-methionine + carminomycin → S-adenosyl-L-homocysteine + H⁺ + daunorubicin

S-adenosyl-L-methionine + 3-O-phospho-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)]_n-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol → S-adenosyl-L-homocysteine + 3-O-methylphospho-α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Man-(1→3)]_n-α-D-Man-(1→3)-α-D-Man-(1→3)-α-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol

S-adenosyl-L-methionine + trans-cinnamate → S-adenosyl-L-homocysteine + methylcinnamate

3 H⁺ + 3 malonyl-CoA + NADPH + S-adenosyl-L-methionine + acetyl-CoA → 3 CO₂ + 4 coenzyme A + H₂O + S-adenosyl-L-homocysteine + 3-methylorcinaldehyde + NADP⁺

S-adenosyl-L-methionine + 3'-O-demethyl-staurosporine → S-adenosyl-L-homocysteine + H⁺ + staurosporine

S-adenosyl-L-methionine + 3,4-dihydroxymandelate → S-adenosyl-L-homocysteine + H⁺ + vanillyl mandelate

S-adenosyl-L-methionine + 4-hydroxybenzoate → S-adenosyl-L-homocysteine + methylparaben

2 S-adenosyl-L-methionine + tricetin → 2 S-adenosyl-L-homocysteine + 2 H⁺ + tricin

S-adenosyl-L-methionine + resorcinol → S-adenosyl-L-homocysteine + 3-methoxyphenol + H⁺

2 S-adenosyl-L-methionine + 3 malonyl-CoA + acetyl-CoA → 2 S-adenosyl-L-homocysteine + 3 CO₂ + 4 coenzyme A + 3,5-dimethylorsellinate

S-adenosyl-L-methionine + kaempferol → S-adenosyl-L-homocysteine + kaempferide + H⁺

O-methyl-4-O-[α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + O-methyl-4-O-[2-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + H⁺

S-adenosyl-L-methionine + precorrin-1 → S-adenosyl-L-homocysteine + precorrin-2

(R)-norlaudanosoline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (R)-N-methylnorlaudanosoline + H⁺

S-adenosyl-L-methionine + 8-demethyl-8-(methylamino)riboflavin → S-adenosyl-L-homocysteine + H⁺ + roseoflavin

S-adenosyl-L-methionine + 1-O-caffeoyl-β-D-glucose → S-adenosyl-L-homocysteine + 1-O-feruloyl-β-D-glucose + H⁺

S-adenosyl-L-methionine + 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-isobutyl-3-vinylbacteriochlorophyllide d + H⁺

S-adenosyl-L-methionine + selgin → S-adenosyl-L-homocysteine + tricin + H⁺

S-adenosyl-L-methionine + 4-demethylpremithracinone → S-adenosyl-L-homocysteine + H⁺ + premithracinone

(S)-demethyl-4-deoxygadusol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (S)-4-deoxygadusol + H⁺

S-adenosyl-L-methionine + quercetin → S-adenosyl-L-homocysteine + H⁺ + 3-O-methylquercetin

3,4-didehydrorhodopin + S-adenosyl-L-methionine → anhydrorhodovibrin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + calycosin → S-adenosyl-L-homocysteine + 2',7-dihydroxy-4',5'-dimethoxyisoflavone

S-adenosyl-L-methionine + laricitrin → S-adenosyl-L-homocysteine + H⁺ + 3,3'-dimethylmyricetin

6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine → 3-methyl-6-methoxy-2-octaprenyl-1,4-benzoquinone + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 3-phenyl-2-oxopropanoate → S-adenosyl-L-homocysteine + H⁺ + (3S)-β-methyl-phenylpyruvate

2 S-adenosyl-L-methionine + demethylated 7,8-dihydromethanopterin → 2 S-adenosyl-L-homocysteine + 7,8-dihydromethanopterin

S-adenosyl-L-methionine + nor-rubrofusarin → S-adenosyl-L-homocysteine + H⁺ + rubrofusarin

5-methoxybenzimidazole + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 5-methoxy-6-methylbenzimidazole + H⁺

S-adenosyl-L-methionine + (-)-pluviatolide → S-adenosyl-L-homocysteine + (-)-bursehernin + H⁺

S-adenosyl-L-methionine + (-)-norephedrine → 2 H⁺ + S-adenosyl-L-homocysteine + (-)-ephedrine

S-adenosyl-L-methionine + isoshowacene → S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H⁺

S-adenosyl-L-methionine + 7,8,4'-trihydroxyflavone → S-adenosyl-L-homocysteine + H⁺ + 7,4'-dihydroxy, 8-methoxyflavone

S-adenosyl-L-methionine + 8-hydroxy-salvigenin → S-adenosyl-L-homocysteine + H⁺ + gardenin B

(S)-coclaurine + S-adenosyl-L-methionine → (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + reumycin → S-adenosyl-L-homocysteine + toxoflavin + H⁺

(S)-tetrahydroprotoberberine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine

S-adenosyl-L-methionine + mercaptohistidine → S-adenosyl-L-homocysteine + ovothiol + H⁺

3 S-adenosyl-L-methionine + 3 L-cysteine + 8 H⁺ + NADPH + (salicyl)adenylate + malonyl-CoA → 3 S-adenosyl-L-homocysteine + 8 H₂O + coenzyme A + NADP⁺ + yersiniabactin + AMP

S-adenosyl-L-methionine + (3¹R)-8,12-diethylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + (3¹R)-8,12-diethylbacteriochlorophyllide c + H⁺

2 S-adenosyl-L-methionine + a reduced electron donor + N-acetyldemethyl-L-phosphinothricin → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricin + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + 6-hydroxy-norbikaverin → S-adenosyl-L-homocysteine + norbikaverin

S-adenosyl-L-methionine + precorrin-4 → S-adenosyl-L-homocysteine + precorrin-5 + H⁺

S-adenosyl-L-methionine + N-acetyl-N6,O-didemethylpuromycin → S-adenosyl-L-homocysteine + H⁺ + N-acetyl-O-demethylpuromycin

11 NADPH + 18 H⁺ + 8 malonyl-CoA + S-adenosyl-L-methionine + acetyl-CoA → 11 NADP⁺ + 6 H₂O + 8 CO₂ + 9 coenzyme A + S-adenosyl-L-homocysteine + dihydromonacolin L lactone

2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-α-D-glucopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-D-desosamine

S-adenosyl-L-methionine + 2-iodophenol → S-adenosyl-L-homocysteine + H⁺ + 2-iodophenol methyl ether

4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine → 2 H⁺ + 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + squalene → S-adenosyl-L-homocysteine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene + H⁺

(+)-taxifolin + S-adenosyl-L-methionine → (+)-3'-methyltaxifolin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + N,N-dimethyl-β-alanine → S-adenosyl-L-homocysteine + β-alanine betaine

S-adenosyl-L-methionine + thiophenol → S-adenosyl-L-homocysteine + thioanisole

S-adenosyl-L-methionine + 3,7-dimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3'-trimethylquercetagetin

N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine → N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 3-O-methylquercetin → S-adenosyl-L-homocysteine + 3,3'-dimethylquercetin

erythromycin C + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + erythromycin A + H⁺

S-adenosyl-L-methionine + isorhamnetin → S-adenosyl-L-homocysteine + 3,3'-dimethylquercetin

phenylethanolamine + S-adenosyl-L-methionine → N-methylphenylethanolamine + S-adenosyl-L-homocysteine + H⁺

chavicol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + methylchavicol

5-hydroxybenzimidazole + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 5-methoxybenzimidazole + H⁺

aklanonate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + methyl aklanonate

S-adenosyl-L-methionine + 26,27-dehydrozymosterol → S-adenosyl-L-homocysteine + 24-alkyl sterol 1

2 S-adenosyl-L-methionine + squalene → 2 S-adenosyl-L-homocysteine + 2 H⁺ + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene

S-adenosyl-L-methionine + demethylmenaquinol-11 → S-adenosyl-L-homocysteine + menaquinol-11 + H⁺

S-adenosyl-L-methionine + rhamnetin → S-adenosyl-L-homocysteine + H⁺ + 7,4'-dimethylquercetin

S-adenosyl-L-methionine + 3-demethylubiquinol-9 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-9

S-adenosyl-L-methionine + 3,4-dihydroxybenzaldehyde → S-adenosyl-L-homocysteine + vanillin + H⁺

S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain → S-adenosyl-L-homocysteine + (+)-pisatin + H⁺

S-adenosyl-L-methionine + gentamicin A → S-adenosyl-L-homocysteine + H⁺ + gentamicin X2

S-adenosyl-L-methionine + cobalt-precorrin-2 → S-adenosyl-L-homocysteine + H⁺ + cobalt-precorrin-3

xanthotoxol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + xanthotoxin

β-alanine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-methyl-β-alanine

S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → S-adenosyl-L-homocysteine + dTDP-2,3,6-trideoxy-3-C-methyl-3-amino-4-dehydro-α-D-glucose + H⁺

S-adenosyl-L-methionine + dTDP-N-monodesmethyl-α-D-forosamine → S-adenosyl-L-homocysteine + dTDP-α-D-forosamine + H⁺

S-adenosyl-L-methionine + 3,7-dimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,4'-trimethylquercetagetin

C33-phthiotriol A + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + C34-phthiocerol A + H⁺

S-adenosyl-L-methionine + genkwanin → S-adenosyl-L-homocysteine + H⁺ + apigenin-7,4'-dimethyl ether

S-adenosyl-L-methionine + norajmaline → S-adenosyl-L-homocysteine + H⁺ + ajmaline

bergaptol + S-adenosyl-L-methionine → bergapten + S-adenosyl-L-homocysteine + H⁺

syringetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,3',5'-trimethylmyricetin

syringetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 7,3',5'-trimethylmyricetin

syringetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3',4',5'-trimethylmyricetin

S-adenosyl-L-methionine + 2-(all-trans-nonaprenyl)benzene-1,4-diol → S-adenosyl-L-homocysteine + 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinol + H⁺

S-adenosyl-L-methionine + 2-hexaprenyl-6-methoxyaminophenol → S-adenosyl-L-homocysteine + H⁺ + 2-hexaprenyl-3-methyl-6-methoxyaminophenol

S-adenosyl-L-methionine + (R)-adrenaline → S-adenosyl-L-homocysteine + H⁺ + metanephrine

S-adenosyl-L-methionine + 3-(all-trans-nonaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 2-methoxy-6-(all-trans-nonaprenyl)phenol

S-adenosyl-L-methionine + catechol → S-adenosyl-L-homocysteine + H⁺ + guaiacol

S-adenosyl-L-methionine + 2'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone → S-adenosyl-L-homocysteine + 2',3'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone + H⁺

myricetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + laricitrin

S-adenosyl-L-methionine + isorhamnetin → S-adenosyl-L-homocysteine + 3',4'-dimethylquercetin

N-dimethylethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + choline + H⁺

S-adenosyl-L-methionine + 12-demethyl-elloramycin → S-adenosyl-L-homocysteine + H⁺ + elloramycin

S-adenosyl-L-methionine + quercetin → S-adenosyl-L-homocysteine + H⁺ + isorhamnetin

S-adenosyl-L-methionine + 2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol

S-adenosyl-L-methionine + sarcosine → S-adenosyl-L-homocysteine + N,N-dimethylglycine + H⁺

S-adenosyl-L-methionine + chondrochloren A → S-adenosyl-L-homocysteine + H⁺ + chondrochloren B

4-methylamino-4-de(dimethylamino)anhydrotetracycline + S-adenosyl-L-methionine → anhydrotetracycline + S-adenosyl-L-homocysteine + H⁺

O-methyl-4-O-[2,4-di-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + p-HBAD-II + H⁺

S-adenosyl-L-methionine + griseophenone D → S-adenosyl-L-homocysteine + H⁺ + griseophenone C

dihydrodemethylsterigmatocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + dihydrosterigmatocystin + H⁺

S-adenosyl-L-methionine + demethylmenaquinol-13 → S-adenosyl-L-homocysteine + menaquinol-13 + H⁺

S-adenosyl-L-methionine + 4-hydroxy-2,2'-bipyrrole-5-carbaldehyde → S-adenosyl-L-homocysteine + H⁺ + 4-methoxy-2,2'-bipyrrole-5-carbaldehyde

S-adenosyl-L-methionine + genistein → S-adenosyl-L-homocysteine + prunetin

3 S-adenosyl-L-methionine + tricaffeoyl spermidine → 3 S-adenosyl-L-homocysteine + 3 H⁺ + triferuloyl spermidine

arsenite + S-adenosyl-L-methionine → methylarsonate + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + mycinamicin VI → S-adenosyl-L-homocysteine + H⁺ + mycinamicin III

S-adenosyl-L-methionine + (R)-noradrenaline → S-adenosyl-L-homocysteine + (R)-adrenaline + H⁺

7-α-hydroxy-O-carbamoyl-deacetylcephalosporin C + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + cephamycin C + H⁺

S-adenosyl-L-methionine + desmethyl-dehydro-dechlorogriseofulvin → S-adenosyl-L-homocysteine + H⁺ + dechloro-dehydrogriseofulvin

S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline → S-adenosyl-L-homocysteine + 17-O-deacetylvindoline + H⁺

S-adenosyl-L-methionine + gentamicin C1a → S-adenosyl-L-homocysteine + H⁺ + gentamicin C2b

1,4-α-D-glucooligosaccharide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units + H⁺

S-adenosyl-L-methionine + (S)-nicotine → S-adenosyl-L-homocysteine + (R)-nicotine isomethonium ion

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone → S-adenosyl-L-homocysteine + H⁺ + gossypetin 3',8-dimethyl ether

6-hydroxytryprostatin B + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + tryprostatin A + H⁺

S-adenosyl-L-methionine + gibberellin A₄ → S-adenosyl-L-homocysteine + methyl gibberellin A₄

ethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-monomethylethanolamine + H⁺

S-adenosyl-L-methionine + apigenin → S-adenosyl-L-homocysteine + genkwanin

3-methylxanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + theobromine + H⁺

S-adenosyl-L-methionine + δ-tocopherol → S-adenosyl-L-homocysteine + H⁺ + β-tocopherol

S-adenosyl-L-methionine + C30 botryococcene → S-adenosyl-L-homocysteine + isoshowacene + H⁺

S-adenosyl-L-methionine + calycosin → S-adenosyl-L-homocysteine + 7-hydroxy-4'5'-dimethoxyisoflavone + H⁺

2 S-adenosyl-L-methionine + a reduced electron donor + N-acetyldemethylphosphinothricin tripeptide → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricin tripeptide + 5'-deoxyadenosine + L-methionine

S-adenosyl-L-methionine + (2S)-eriodictyol → (2S)-hesperetin + S-adenosyl-L-homocysteine + H⁺

methylarsonite + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + cacodylate

S-adenosyl-L-methionine + (R)-nicotine → S-adenosyl-L-homocysteine + (R)-nicotine isomethonium ion

5-hydroxyxanthotoxin + S-adenosyl-L-methionine → isopimpinellin + S-adenosyl-L-homocysteine + H⁺

2 S-adenosyl-L-methionine + N-acetyldemethylphosphinothricyl-L-alanyl-L-leucine + a reduced electron donor → 2 H⁺ + an oxidized electron donor + S-adenosyl-L-homocysteine + N-acetylphosphinothricyl-L-alanyl-L-leucine + 5'-deoxyadenosine + L-methionine

(S)-scoulerine + S-adenosyl-L-methionine → (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 2,4,6-trichlorophenol → trichloroanisole + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + 3,7,4'-trimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,4'-tetramethylquercetagetin

S-adenosyl-L-methionine + tricetin → S-adenosyl-L-homocysteine + H⁺ + selgin

S-adenosyl-L-methionine + dTDP-4-dehydro-2,6-dideoxy-α-D-allose → S-adenosyl-L-homocysteine + dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-L-allose + H⁺

S-adenosyl-L-methionine + trihydroxyferuloyl spermidine → S-adenosyl-L-homocysteine + H⁺ + dihydroxyferuloyl-sinapoyl spermidine

S-adenosyl-L-methionine + coniferyl alcohol → S-adenosyl-L-homocysteine + coniferyl alcohol 9-methyl ester + H⁺

(2S)-naringenin + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + ponciretin

S-adenosyl-L-methionine + demethylmenaquinol-4 → S-adenosyl-L-homocysteine + menaquinol-4 + H⁺

S-adenosyl-L-methionine + (S)-isoandrocymbine → S-adenosyl-L-homocysteine + H⁺ + O-methylandrocymbine

S-adenosyl-L-methionine + 1-(3,4-dihydroxyphenyl)-5-hydroxy-3-decanone → S-adenosyl-L-homocysteine + 6-gingerol + H⁺

S-adenosyl-L-methionine + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin 3'-O-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,2',4'-pentamethylquercetagetin 3'-O-β-D-glucoside

S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-α-L-rhamnosyl)-tetracenomycin C → S-adenosyl-L-homocysteine + H⁺ + 12-demethyl-elloramycin

S-adenosyl-L-methionine + 2-demethylmenaquinone-8 → menaquinone-8 + S-adenosyl-L-homocysteine + H⁺

norbelladine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 4'-O-methylnorbelladine + H⁺

S-adenosyl-L-methionine + mycinamicin III → S-adenosyl-L-homocysteine + H⁺ + mycinamicin IV

xanthosine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 7-methylxanthosine

3-methoxy-5-hydroxytoluene + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dimethoxytoluene + H⁺

3'-hydroxy-N-methyl-(S)-coclaurine + S-adenosyl-L-methionine → (S)-reticuline + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 3-hexaprenyl-4-amino-5-hydroxybenzoate → S-adenosyl-L-homocysteine + H⁺ + 3-hexaprenyl-4-amino-5-methoxybenzoate

H₂O + S-adenosyl-L-methionine + precorrin-5 → acetate + S-adenosyl-L-homocysteine + precorrin-6A + H⁺

S-adenosyl-L-methionine + 8-hydroxy-7-methoxy-flavone → S-adenosyl-L-homocysteine + H⁺ + 7,8-dimethoxy-flavone

S-adenosyl-L-methionine + C34-phenolphthiotriol A → S-adenosyl-L-homocysteine + C35-phenolphthiocerol A + H⁺

glycine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + sarcosine + H⁺

S-adenosyl-L-methionine + 8-demethyl-8-(2-O-methyl-α-L-rhamnosyl)-tetracenomycin C → S-adenosyl-L-homocysteine + H⁺ + 8-demethyl-8-(2,3-O-dimethyl-α-L-rhamnosyl)-tetracenomycin C

S-adenosyl-L-methionine + demethylmenaquinol-6 → S-adenosyl-L-homocysteine + menaquinol-6 + H⁺

S-adenosyl-L-methionine + 3,7-dimethylquercetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,4'-trimethylquercetin

S-adenosyl-L-methionine + gibberellin A₃₄ → S-adenosyl-L-homocysteine + methyl gibberellin A₃₄

(S)-scoulerine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (S)-2-methylscoulerine + H⁺

S-adenosyl-L-methionine + gentamicin C2 → S-adenosyl-L-homocysteine + H⁺ + gentamicin C1

S-adenosyl-L-methionine + dTDP-β-L-4-epi-vancosamine → S-adenosyl-L-homocysteine + dTDP-β-L-evernosamine + H⁺

S-adenosyl-L-methionine + 2-demethylmenaquinone-9 → menaquinone-9 + S-adenosyl-L-homocysteine + H⁺

L-dopa + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-O-methyldopa

S-adenosyl-L-methionine + 1,6-didemethyltoxoflavin → S-adenosyl-L-homocysteine + 6-demethyltoxoflavin + H⁺

S-adenosyl-L-methionine + laricitrin → S-adenosyl-L-homocysteine + H⁺ + 3',4'-dimethylmyricetin

S-adenosyl-L-methionine + noraucuparin → S-adenosyl-L-homocysteine + aucuparin + H⁺

S-adenosyl-L-methionine + precorrin-3B → 2 H⁺ + S-adenosyl-L-homocysteine + precorrin-4

3,6,7-trimethylquercetagetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,4'-tetramethylquercetagetin

(-)-catechin + S-adenosyl-L-methionine → (-)-3'-methylcatechin + S-adenosyl-L-homocysteine + H⁺

L-selenomethionine + S-adenosyl-L-methionine → Se-methyl-Se-L-methionine + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + 3-(all-trans-decaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 6-(all-trans-decaprenyl)-2-methoxy-phenol

salicylate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + methylsalicylate

2 S-adenosyl-L-methionine + dTDP-3-amino-3,6-dideoxy-α-D-galactopyranose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-D-ravidosamine

S-adenosyl-L-methionine + columbamine → palmatine + S-adenosyl-L-homocysteine + H⁺

2 ATP + anthranilate + S-adenosyl-L-methionine + L-phenylalanine → 2 H⁺ + 2 diphosphate + 2 AMP + S-adenosyl-L-homocysteine + cyclopeptine

S-adenosyl-L-methionine + (-)-matairesinol → S-adenosyl-L-homocysteine + arctigenin + H⁺

S-adenosyl-L-methionine + pilosin → S-adenosyl-L-homocysteine + H⁺ + nevadensin

N-demethylindolmycin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + indolmycin

8-demethylnovobiocic acid + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + novobiocic acid + H⁺

S-adenosyl-L-methionine + patuletin → S-adenosyl-L-homocysteine + H⁺ + eupatolitin

S-adenosyl-L-methionine + L-leucyl-demethylarginomycin → S-adenosyl-L-homocysteine + H⁺ + L-leucyl-arginomycin

S-adenosyl-L-methionine + 2-(2,4-dihydroxy-6-methylbenzoyl)benzene-1,3,5-triol → S-adenosyl-L-homocysteine + H⁺ + griseophenone D

S-adenosyl-L-methionine + (indol-3-yl)pyruvate → S-adenosyl-L-homocysteine + H⁺ + (R)-3-(indol-3-yl)-2-oxobutanoate

2,4',5,7-tetrahydroxyisoflavanone + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + 2,5,7-trihydroxy-4'-methoxyisoflavanone

3,4-dihydroxy-5-all-trans-octaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-octaprenylbenzoate

S-adenosyl-L-methionine + demethylphylloquinol → phylloquinol + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + tyramine → S-adenosyl-L-homocysteine + N-methyltyramine + H⁺

S-adenosyl-L-methionine + luteolin → S-adenosyl-L-homocysteine + H⁺ + chrysoeriol

S-adenosyl-L-methionine + cycloartenol → S-adenosyl-L-homocysteine + (24R)-24-methylcycloarta-25-en-3-β-ol + H⁺

S-adenosyl-L-methionine + 2'-hydroxy 3,7,4'-trimethylquercetin → S-adenosyl-L-homocysteine + H⁺ + 2'-hydroxy 3,7,3',4'-tetramethylquercetin

S-adenosyl-L-methionine + all trans-decaprenyl-2-methoxy-6-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-decaprenyl-1,4-benzoquinol

S-adenosyl-L-methionine + 10-carboxy-3-deoxycarminomycin → S-adenosyl-L-homocysteine + H⁺ + 10-carboxy-13-deoxydaunorubicin

S-adenosyl-L-methionine + 1-hydroxyglucobrassicin → S-adenosyl-L-homocysteine + H⁺ + neoglucobrassicin

S-adenosyl-L-methionine + (2E,6E)-farnesoate → S-adenosyl-L-homocysteine + methyl (2E,6E)-farnesoate

2,4-dibromo-6-(2,4-dibromophenoxy)phenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 1,5-dibromo-3-(2,4-dibromophenoxy)-2-methoxybenzene

xanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-methylxanthine + H⁺

S-adenosyl-L-methionine + 3,7,3'-trimethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,3'-tetramethylquercetagetin

2 S-adenosyl-L-methionine + 3-(aminomethyl)indole → 2 S-adenosyl-L-homocysteine + 2 H⁺ + gramine

S-adenosyl-L-methionine + rhamnetin → S-adenosyl-L-homocysteine + H⁺ + 7,3'-dimethylquercetin

S-adenosyl-L-methionine + precorrin-6B + H⁺ → S-adenosyl-L-homocysteine + precorrin-7 + CO₂

S-adenosyl-L-methionine + trans-aconitate → S-adenosyl-L-homocysteine + (E)-2-(methoxycarbonylmethyl)butenedioate

S-adenosyl-L-methionine + (S)-corytuberine → S-adenosyl-L-homocysteine + H⁺ + (S)-magnoflorine

S-adenosyl-L-methionine + N-acetyl-serotonin → S-adenosyl-L-homocysteine + H⁺ + melatonin

S-adenosyl-L-methionine + 17-O-acetylnorajmaline → S-adenosyl-L-homocysteine + H⁺ + 17-O-acetylajmaline

S-adenosyl-L-methionine + isoorientin → isoscoparine + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + (-)-jasmonate → S-adenosyl-L-homocysteine + (-)-methyl jasmonate

macrocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + tylosin

S-adenosyl-L-methionine + benzoate → S-adenosyl-L-homocysteine + methyl benzoate

S-adenosyl-L-methionine + 3,4-dihydroxyphenylacetate → S-adenosyl-L-homocysteine + H⁺ + homovanillate

S-adenosyl-L-methionine + dTDP-4-dehydro-β-L-rhamnose → S-adenosyl-L-homocysteine + dTDP-4-dehydro-5-methyl-β-L-rhamnose + H⁺

S-adenosyl-L-methionine + L-selenocysteine → S-adenosyl-L-homocysteine + H⁺ + Se-methyl-L-selenocysteine

S-adenosyl-L-methionine + 16-hydroxytabersonine → S-adenosyl-L-homocysteine + 16-methoxytabersonine + H⁺

S-adenosyl-L-methionine + H⁺ + cobalt-precorrin-3 → S-adenosyl-L-homocysteine + cobalt-precorrin-4

S-adenosyl-L-methionine + L-glutamate + oxygen + gentamicin A2 → hydrogen peroxide + S-adenosyl-L-homocysteine + 2-oxoglutarate + H⁺ + gentamicin A

S-adenosyl-L-methionine + 2-methoxy-6-all trans-nonaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-nonaprenyl-1,4-benzoquinol

S-adenosyl-L-methionine + daidzein → S-adenosyl-L-homocysteine + isoformononetin + H⁺

S-adenosyl-L-methionine + welwitindolinone C isothiocyanate → S-adenosyl-L-homocysteine + H⁺ + N-methylwelwitindolinone C isothiocyanate

sterigmatocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 8-O-methylsterigmatocystin + H⁺

S-adenosyl-L-methionine + trans-aconitate → (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + cobalt-precorrin-6B → S-adenosyl-L-homocysteine + H⁺ + cobalt-precorrin-7

S-adenosyl-L-methionine + N-acetyl-O-demethylpuromycin → S-adenosyl-L-homocysteine + H⁺ + N-acetylpuromycin

S-adenosyl-L-methionine + paraxanthine → S-adenosyl-L-homocysteine + caffeine + H⁺

(2S)-naringenin + S-adenosyl-L-methionine → (2S)-sakuranetin + S-adenosyl-L-homocysteine + H⁺

2 S-adenosyl-L-methionine + S-demethyl-thiocoraline dithiol → 2 S-adenosyl-L-homocysteine + 2 H⁺ + thiocoraline dithiol

S-adenosyl-L-methionine + N-methyl-β-alanine → S-adenosyl-L-homocysteine + N,N-dimethyl-β-alanine

(R)-demethyl-4-deoxygadusol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (R)-4-deoxygadusol + H⁺

S-adenosyl-L-methionine + trans-resveratrol → S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene + H⁺

L-homocysteine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + L-methionine

S-adenosyl-L-methionine + showacene → S-adenosyl-L-homocysteine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene + H⁺

S-adenosyl-L-methionine + 3-hydroxy-5-methyl-L-tyrosine → S-adenosyl-L-homocysteine + H⁺ + 4O,5-dimethyl,3-hydroxy L-tyrosine

pretetramide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 6-methylpretetramide + H⁺

S-adenosyl-L-methionine + bromide → S-adenosyl-L-homocysteine + methyl bromide

2 S-adenosyl-L-methionine + uroporphyrinogen-III → 2 S-adenosyl-L-homocysteine + precorrin-2 + H⁺

S-adenosyl-L-methionine + eugenol → S-adenosyl-L-homocysteine + methyleugenol + H⁺

S-adenosyl-L-methionine + apigenin → S-adenosyl-L-homocysteine + H⁺ + acacetin

S-adenosyl-L-methionine + 3-O-methylquercetin → S-adenosyl-L-homocysteine + 3,7-dimethylquercetin

7-methylxanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + theobromine + H⁺

carnosine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + anserine

S-adenosyl-L-methionine + DIBOA-β-D-glucoside → S-adenosyl-L-homocysteine + 4-O-methyl-DIBOA-glucoside + H⁺

S-adenosyl-L-methionine + N^α,N^α-dimethyl-L-histidine → S-adenosyl-L-homocysteine + H⁺ + hercynine

S-adenosyl-L-methionine + 4-hydroxyglucobrassicin → S-adenosyl-L-homocysteine + H⁺ + 4-methoxyglucobrassicin

S-adenosyl-L-methionine + 12-hydroxydihydrochelirubine → S-adenosyl-L-homocysteine + dihydromacarpine + H⁺

S-adenosyl-L-methionine + (-)-5'-demethylyatein → S-adenosyl-L-homocysteine + (-)-yatein + H⁺

S-adenosyl-L-methionine + 12-ethyl-8-isobutylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-isobutylbacteriochlorophyllide c + H⁺

S-adenosyl-L-methionine + welwitindolinone B isothiocyanate → S-adenosyl-L-homocysteine + H⁺ + N-methylwelwitindolinone B isothiocyanate

S-adenosyl-L-methionine + glandicoline B → S-adenosyl-L-homocysteine + H⁺ + meleagrin

S-adenosyl-L-methionine + fusarubinaldehyde → S-adenosyl-L-homocysteine + H⁺ + 8-O-methylfusarubinaldehyde

demethylspheroidene + S-adenosyl-L-methionine → spheroidene + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + daidzein → S-adenosyl-L-homocysteine + H⁺ + formononetin

S-adenosyl-L-methionine + 3-(aminomethyl)indole → S-adenosyl-L-homocysteine + H⁺ + (1H-indol-3-yl)-N-methylmethanamine

S-adenosyl-L-methionine + dopamine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxytyramine

theobromine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + caffeine + H⁺

S-adenosyl-L-methionine + γ-tocotrienol → S-adenosyl-L-homocysteine + H⁺ + α-tocotrienol

S-adenosyl-L-methionine + 3-(all-trans-heptaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 2-methoxy-6-(all-trans-heptaprenyl)phenol

S-adenosyl-L-methionine + cobalt-sirohydrochlorin → S-adenosyl-L-homocysteine + H⁺ + cobalt-factor III

S-adenosyl-L-methionine + 3,7-dimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3'-trimethylmyricetin

S-adenosyl-L-methionine + (4'R)-10',11'-dihydroxy-5'-azaspiro[cyclohexane-1,2'-tricyclo[6.3.1.04,ï¿½ï¿½]dodecane]-'(12'),2,5,8',10'-pentaen-4-one → S-adenosyl-L-homocysteine + H⁺ + crotonosine

nicotinate + S-adenosyl-L-methionine → trigonelline + S-adenosyl-L-homocysteine

(S)-tetrahydrocolumbamine + S-adenosyl-L-methionine → (S)-tetrahydropalmatine + S-adenosyl-L-homocysteine + H⁺

2 ATP + anthranilate + S-adenosyl-L-methionine + O-methyl-L-tyrosine → 2 H⁺ + 2 diphosphate + 2 AMP + S-adenosyl-L-homocysteine + 4'-methoxycyclopeptine

3-hydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine → 3-methoxy-5-methyl-1-naphthoate + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 5-pentadecatrienyl resorcinol → S-adenosyl-L-homocysteine + H⁺ + 5-pentadecatrienyl resorcinol-3-methyl ether

(R)-norcoclaurine + S-adenosyl-L-methionine → (R)-coclaurine + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + methanol + H⁺ + 26,27-dehydrozymosterol → S-adenosyl-L-homocysteine + 24-alkyl sterol 2 + a methyl group

S-adenosyl-L-methionine + (2S)-eriodictyol → S-adenosyl-L-homocysteine + homoeriodictyol + H⁺

S-adenosyl-L-methionine + 5-hydroxy-coniferaldehyde → S-adenosyl-L-homocysteine + sinapaldehyde + H⁺

S-adenosyl-L-methionine + (S)-laudanine → S-adenosyl-L-homocysteine + H⁺ + (S)-laudanosine

S-adenosyl-L-methionine + 2-methoxy-6-all trans-heptaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-heptaprenyl-1,4-benzoquinol

S-adenosyl-L-methionine + 6-O-demethylfusarubinaldehyde → S-adenosyl-L-homocysteine + H⁺ + fusarubinaldehyde

S-adenosyl-L-methionine + coniine → S-adenosyl-L-homocysteine + H⁺ + methylconiine

S-adenosyl-L-methionine + 2-methyl-6-phytyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + 2,3-dimethyl-6-phytyl-1,4-benzoquinol + H⁺

S-adenosyl-L-methionine + trichosetin → S-adenosyl-L-homocysteine + H⁺ + equisetin

S-adenosyl-L-methionine + esculetin → S-adenosyl-L-homocysteine + H⁺ + scopoletin

S-adenosyl-L-methionine + 3',4',5'-trimethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 7,3',4',5'-tetramethylmyricetin

S-adenosyl-L-methionine + demethylmenaquinol-9 → S-adenosyl-L-homocysteine + menaquinol-9 + H⁺

6-hydroxymellein + S-adenosyl-L-methionine → 6-methoxymellein + S-adenosyl-L-homocysteine + H⁺

desmethyl gadusol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + gadusol + H⁺

S-adenosyl-L-methionine + malonyl-CoA → S-adenosyl-L-homocysteine + malonyl-CoA methyl ester

S-adenosyl-L-methionine + γ-tocopherol → S-adenosyl-L-homocysteine + H⁺ + α-tocopherol

7-methylxanthine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + paraxanthine + H⁺

S-adenosyl-L-methionine + 8,12-diethyl-3-vinylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + 12-ethyl-8-propyl-3-vinylbacteriochlorophyllide d + H⁺

S-adenosyl-L-methionine + 7-O-methylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 7,4'-dimethylmyricetin

S-adenosyl-L-methionine + dimethyl sulfide → S-adenosyl-L-homocysteine + trimethyl sulfonium

S-adenosyl-L-methionine + H⁺ + cobalt-precorrin-6B → S-adenosyl-L-homocysteine + CO₂ + cobalt-precorrin-7

S-adenosyl-L-methionine + L-tyrosine → S-adenosyl-L-homocysteine + H⁺ + 3-methyl-L-tyrosine

2 S-adenosyl-L-methionine + trans-resveratrol → 2 S-adenosyl-L-homocysteine + 2 H⁺ + pterostilbene

3 S-adenosyl-L-methionine + tricetin → 3 S-adenosyl-L-homocysteine + 3 H⁺ + 3',4',5'-O-trimethyltricetin

S-adenosyl-L-methionine + patuletin → S-adenosyl-L-homocysteine + H⁺ + quercetagetin 3',6-dimethyl ether

S-adenosyl-L-methionine + (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine → S-adenosyl-L-homocysteine + deacetoxyvindoline + H⁺

S-adenosyl-L-methionine + furfuryl thiol → S-adenosyl-L-homocysteine + H⁺ + furfuryl methyl sulfide

1-hydroxyneurosporene + S-adenosyl-L-methionine → methoxyneurosporene + S-adenosyl-L-homocysteine + H⁺

N-demethylgalanthamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + galanthamine + H⁺

S-adenosyl-L-methionine + ladanein → S-adenosyl-L-homocysteine + H⁺ + salvigenin

S-adenosyl-L-methionine + gibberellin A₂₀ → S-adenosyl-L-homocysteine + methyl gibberellin A₂₀

N-monomethylethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-dimethylethanolamine + H⁺

(2S)-pinocembrin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + pinostrobin

S-adenosyl-L-methionine + desmethyl-dehydro-griseofulvin → S-adenosyl-L-homocysteine + H⁺ + dehydrogriseofulvin

S-adenosyl-L-methionine + ajmaline → S-adenosyl-L-homocysteine + N_β-methylajmaline

pinosylvin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + pinosylvin monomethylether + H⁺

S-adenosyl-L-methionine + methanol + H⁺ + 26,27-dehydrozymosterol → S-adenosyl-L-homocysteine + 26-hydroxy-27-methyl-zymosterol + a methyl group

kaempferide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 7,4'-dimethylkaempferol

demethylsulochrin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + sulochrin

baeocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + psilocybin + H⁺

3,5-dihydroxyanisole + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dimethoxyphenol + H⁺

S-adenosyl-L-methionine + carboxy-fusarin C → S-adenosyl-L-homocysteine + fusarin C

fusicocca-1,10(14)-diene-3,8β,16-triol + S-adenosyl-L-methionine → fusicocca-1,10(14)-diene-16-(hydroxymethyl)-3,8β-diol + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + quercetagetin → S-adenosyl-L-homocysteine + H⁺ + patuletin

juvenile hormone III acid + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + juvenile hormone III

3-hydroxyanthranilate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-hydroxy-4-methylanthranilate + H⁺

S-adenosyl-L-methionine + (1H-indol-3-yl)-N-methylmethanamine → S-adenosyl-L-homocysteine + H⁺ + gramine

S-adenosyl-L-methionine + (-)-vestitol → S-adenosyl-L-homocysteine + (-)-sativan + H⁺

(R,S)-tetrahydrobenzylisoquinoline + S-adenosyl-L-methionine → N-methyl-(R,S)-tetrahydrobenzylisoquinoline + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 7-O-methylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7-dimethylmyricetin

S-adenosyl-L-methionine + 3-O-methylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7-dimethylmyricetin

2,4-dibromo-6-(2,4-dibromo-6-hydroxyphenoxy)phenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3,5-dibromo-2-(3,5-dibromo-2-methoxyphenoxy)phenol + H⁺

O-demethylpuromycin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + puromycin + H⁺

S-adenosyl-L-methionine + 3,6,7,4'-tetramethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,3',4'-pentamethylquercetagetin

S-adenosyl-L-methionine + C36-phenolphthiotriol A → S-adenosyl-L-homocysteine + C37-phenolphthiocerol A + H⁺

S-adenosyl-L-methionine + N,N-dimethylglycine → glycine betaine + S-adenosyl-L-homocysteine + H⁺

6-demethylsterigmatocystin + S-adenosyl-L-methionine → sterigmatocystin + S-adenosyl-L-homocysteine + H⁺

2 S-adenosyl-L-methionine + dTDP-3-amino-4-dehydro-2,3,6-trideoxy-α-D-glucose → 2 S-adenosyl-L-homocysteine + 2 H⁺ + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose

S-adenosyl-L-methionine + scutellarein 7-methyl ether → S-adenosyl-L-homocysteine + cirsimaritin + H⁺

S-adenosyl-L-methionine + tetracenomycin B3 → S-adenosyl-L-homocysteine + H⁺ + tetracenomycin E

S-adenosyl-L-methionine + 6-O-methyl-N-deacetylisoipecoside aglycon → S-adenosyl-L-homocysteine + H⁺ + 6,7-O,O-dimethyl-N-deacetylisoipecoside aglycon

S-adenosyl-L-methionine + L-histidine → S-adenosyl-L-homocysteine + H⁺ + N^α-methyl-L-histidine

anthranilate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + N-methylanthranilate

S-adenosyl-L-methionine + 3,7-dimethylquercetagetin → S-adenosyl-L-homocysteine + 3,6,7-trimethylquercetagetin + H⁺

S-adenosyl-L-methionine + 2-sulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA → S-adenosyl-L-homocysteine + H⁺ + 2-methylsulfanyl-N⁶-dimethylallyladenosine³⁷ in tRNA

vitexin 2''-O-β-L-rhamnoside + S-adenosyl-L-methionine → 7-O-methylvitexin 2''-O-β-L-rhamnoside + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + 27-O-demethyl-rifamycin SV → S-adenosyl-L-homocysteine + H⁺ + rifamycin SV

S-adenosyl-L-methionine + thiobenzoate → S-adenosyl-L-homocysteine + H⁺ + (S)-methyl thiobenzoate

(R)-norreticuline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (R)-N-methylnorreticuline + H⁺

2 S-adenosyl-L-methionine + 8-amino-8-demethylriboflavin → 2 S-adenosyl-L-homocysteine + 2 H⁺ + roseoflavin

S-adenosyl-L-methionine + 2-methyl-6-all-trans-nonaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + plastoquinol-9 + H⁺

4-O-(α-L-rhamnopyranosyl)-hydroxybenzoate methyl ester + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + p-HBAD-I + H⁺

3,4-dihydroxy-5-all-trans-decaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-decaprenylbenzoate

2 S-adenosyl-L-methionine + scutellarein 7-methyl ether → 2 S-adenosyl-L-homocysteine + 2 H⁺ + salvigenin

2 ATP + S-adenosyl-L-methionine + (S)-1-pyrroline-5-carboxylate + L-arginine → 2 H⁺ + 2 diphosphate + 2 AMP + H₂O + S-adenosyl-L-homocysteine + peramine

S-adenosyl-L-methionine + 7'-O-demethylcephaeline → S-adenosyl-L-homocysteine + H⁺ + cephaeline

9-N-hydroxy-L-tryptophan + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 9-N-methoxy-tryptophan

S-adenosyl-L-methionine + mono(methylsulfanyl)gliotoxin → S-adenosyl-L-homocysteine + H⁺ + bis(methylsulfanyl)gliotoxin

xanthohumol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 4-O-methylxanthohumol + H⁺

S-adenosyl-L-methionine + 5-hydroxy-desmethylanthrotainin → S-adenosyl-L-homocysteine + H⁺ + 5-hydroxyanthrotainin

demethyllactenocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + lactenocin + H⁺

S-adenosyl-L-methionine + 3'-O-demethyl-4'-N-demethyl-staurosporine → S-adenosyl-L-homocysteine + H⁺ + 3'-O-demethyl-staurosporine

demethyldecarbamoyl novobiocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + decarbamoylnovobiocin + H⁺

S-adenosyl-L-methionine + 6-demethylmitomycin A → S-adenosyl-L-homocysteine + mitomycin A

zymosterol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + fecosterol + H⁺

S-adenosyl-L-methionine + demethylmenaquinol-7 → S-adenosyl-L-homocysteine + menaquinol-7 + H⁺

S-adenosyl-L-methionine + L-leucyl-demethyl-blasticidin S → S-adenosyl-L-homocysteine + H⁺ + L-leucyl-blasticidin S

S-adenosyl-L-methionine + 3-demethylubiquinol-8 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-8

S-stylopine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (S)-cis-N-methylstylopine

tellurite + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + methanetelluronate

2 L-cysteine + salicylate + NADPH + S-adenosyl-L-methionine → 4 H₂O + S-adenosyl-L-homocysteine + NADP⁺ + pyochelin

S-adenosyl-L-methionine + 3-methyl-1,2-didehydro-2,3-dihydrosqualene → S-adenosyl-L-homocysteine + 3,22-dimethyl-1,2,23,24-tetradehydro-2,3,22,23-tetrahydrosqualene + H⁺

S-adenosyl-L-methionine + triostin A → S-adenosyl-L-homocysteine + echinomycin + H⁺

S-adenosyl-L-methionine + licodione → S-adenosyl-L-homocysteine + 2'-O-methyllicodione + H⁺

S-adenosyl-L-methionine + tetracenomycin D3 → S-adenosyl-L-homocysteine + tetracenomycin B3

S-adenosyl-L-methionine + demethyldehydrophos → S-adenosyl-L-homocysteine + dehydrophos

S-adenosyl-L-methionine + rhamnetin → S-adenosyl-L-homocysteine + H⁺ + 3,7-dimethylquercetin

histamine + S-adenosyl-L-methionine → N^τ-methylhistamine + S-adenosyl-L-homocysteine + H⁺

11-hydroxyvittatine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + hemanthamine + H⁺

S-adenosyl-L-methionine + 8-hydroxykaempferol → S-adenosyl-L-homocysteine + H⁺ + 8-methoxykaempferol

S-adenosyl-L-methionine + pyridine → S-adenosyl-L-homocysteine + N-Methylpyridinium

3,5-dimethoxyphenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 1,3,5-trimethoxybenzene + H⁺

S-adenosyl-L-methionine + (-)-matairesinol → S-adenosyl-L-homocysteine + isoarctigenin + H⁺

S-adenosyl-L-methionine + dithiolgliotoxin → S-adenosyl-L-homocysteine + H⁺ + mono(methylsulfanyl)gliotoxin

S-adenosyl-L-methionine + cirsiliol → S-adenosyl-L-homocysteine + H⁺ + cirsilineol

lactenocin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + desmycosin + H⁺

S-adenosyl-L-methionine + iodide → S-adenosyl-L-homocysteine + methyl iodide

S-adenosyl-L-methionine + cycloartenol → S-adenosyl-L-homocysteine + H⁺ + 24-methylenecycloartanol

S-adenosyl-L-methionine + 3,7,3',5'-tetramethylmyricetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',4',5'-pentamethylmyricetin

S-adenosyl-L-methionine + gossypetin → S-adenosyl-L-homocysteine + H⁺ + 3,3',4',5,7-pentahydroxy-8-methoxyflavone

erythromycin D + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + erythromycin B + H⁺

S-adenosyl-L-methionine + quercetagetin 7-O-glucoside → S-adenosyl-L-homocysteine + H⁺ + patulitrin

S-adenosyl-L-methionine + 5-guanidino-2-oxopentanoate → S-adenosyl-L-homocysteine + 5-guanidino-3-methyl-2-oxopentanoate + H⁺

(±)-pavine + S-adenosyl-L-methionine → 2 H⁺ + S-adenosyl-L-homocysteine + N-methylpavine

S-adenosyl-L-methionine + deacetylisoipecoside → S-adenosyl-L-homocysteine + H⁺ + 6-O-methyl-N-deacetylisoipecoside

S-adenosyl-L-methionine + 1,6-didemethyltoxoflavin → S-adenosyl-L-homocysteine + reumycin + H⁺

S-adenosyl-L-methionine + gentamicin X2 → S-adenosyl-L-homocysteine + H⁺ + G-418

S-adenosyl-L-methionine + tricin → S-adenosyl-L-homocysteine + 3',4',5'-O-trimethyltricetin + H⁺

S-adenosyl-L-methionine + 5-hydroxyferulate → S-adenosyl-L-homocysteine + sinapate + H⁺

S-adenosyl-L-methionine + tetracenomycin E → S-adenosyl-L-homocysteine + tetracenomycin A2

S-adenosyl-L-methionine + precorrin-2 → S-adenosyl-L-homocysteine + precorrin-3A + H⁺

xanthohumol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 2',4-dihydroxy-4',6'-dimethoxy-3'-prenylchalcone

S-adenosyl-L-methionine + L-methionine → S-adenosyl-L-homocysteine + S-methyl-L-methionine

(S)-canadine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + (S)-N-methylcanadine

2 S-adenosyl-L-methionine + precorrin-6B → 2 S-adenosyl-L-homocysteine + 2 H⁺ + precorrin-8x + CO₂

S-adenosyl-L-methionine + emodin → questin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + 13-dihydrocarminomycin → S-adenosyl-L-homocysteine + H⁺ + 13-dihydrodaunorubicin

O-methyl-4-O-[2-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + O-methyl-4-O-[2,4-di-O-methyl-α-L-fucopyranosyl-(1→3)-α-L-rhamnopyranosyl-(1→3)-2-O-methyl-α-L-rhamnopyranosyl]-hydroxybenzoate + H⁺

S-adenosyl-L-methionine + cirsimaritin → S-adenosyl-L-homocysteine + H⁺ + salvigenin

S-adenosyl-L-methionine + N^α-methyl-L-histidine → S-adenosyl-L-homocysteine + H⁺ + N^α,N^α-dimethyl-L-histidine

2,7-dihydroxy-5-methyl-1-naphthoate + S-adenosyl-L-methionine → 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + chloride → S-adenosyl-L-homocysteine + methyl chloride

S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol → S-adenosyl-L-homocysteine + H⁺ + 2-methoxy-6-(all-trans-octaprenyl)phenol

S-adenosyl-L-methionine + thiocyanate → S-adenosyl-L-homocysteine + methyl thiocyanate

S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranose → S-adenosyl-L-homocysteine + dTDP-N-monodesmethyl-α-D-forosamine + H⁺

3,5-dibromo-2-(2,4-dibromophenoxy)phenol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 1,5-dibromo-2-(2,4-dibromophenoxy)-3-methoxybenzene

S-adenosyl-L-methionine + β-D-glucuronosyl-(1→4)-α-D-galacturonosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate) → S-adenosyl-L-homocysteine + H⁺ + methyl-O-4-β-D-glucuronosyl-(1→4)-α-D-galacturonosyl-(1→4)-β-D-glucuronosyl-(1→4)-β-D-glucosyl-(C55 ω-saturated dolichyl phosphate)

(S)-reticuline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + (S)-laudanine

norbaeocystin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + baeocystin + H⁺

S-adenosyl-L-methionine + 2-methyl-6-geranylgeranyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + 2,3-dimethyl-6-geranylgeranyl-1,4-benzoquinol + H⁺

nicotinamide + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 1-methylnicotinamide

S-adenosyl-L-methionine + dTDP-3-N-methylamino-4-oxo-2,3,6-trideoxy-α-D-glucose → S-adenosyl-L-homocysteine + dTDP-3-N,N-dimethylamino-4-oxo-2,3,6-trideoxy-α-D-glucose + H⁺

S-adenosyl-L-methionine + 2',7-dihydroxy-4',5'-dimethoxyisoflavone → S-adenosyl-L-homocysteine + 7-hydroxy-2',4',5'-trimethoxyisoflavone + H⁺

guanidinoacetate + S-adenosyl-L-methionine → creatine + S-adenosyl-L-homocysteine + H⁺

anthranilate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + O-methyl anthranilate

S-adenosyl-L-methionine + trans-caffeoyl-CoA → S-adenosyl-L-homocysteine + H⁺ + trans-feruloyl-CoA

S-adenosyl-L-methionine + 3,4-dihydroxyphenylglycol → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxyphenylglycol

S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene → S-adenosyl-L-homocysteine + pterostilbene + H⁺

loganate + S-adenosyl-L-methionine → loganin + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + isoeugenol → S-adenosyl-L-homocysteine + H⁺ + isomethyleugenol

S-adenosyl-L-methionine + 31-O-desmethylFK-506 → S-adenosyl-L-homocysteine + H⁺ + FK-506

O-phosphoethanolamine + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + N-methylethanolamine phosphate + H⁺

S-adenosyl-L-methionine + 5-hydroxymethylcytosine → S-adenosyl-L-homocysteine + H⁺ + bacimethrin

2 S-adenosyl-L-methionine + C30 botryococcene → 2 S-adenosyl-L-homocysteine + 2 H⁺ + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene

3 S-adenosyl-L-methionine + 3 H⁺ + 3 L-cysteine + 6 NADPH + (salicyl)adenylate + malonyl-CoA → 3 S-adenosyl-L-homocysteine + 6 NADP⁺ + 8 H₂O + coenzyme A + yersiniabactin + AMP

(S)-norlaudanosoline + S-adenosyl-L-methionine → 6-O-methylnorlaudanosoline + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + dTDP-4-dehydro-2,6-dideoxy-α-D-threo-hexopyranose → S-adenosyl-L-homocysteine + dTDP-4-dehydro-3-C-methyl-2,6-dideoxy-α-D-glucose + H⁺

S-adenosyl-L-methionine + 3,5-dihydroxybiphenyl → S-adenosyl-L-homocysteine + 3-hydroxy-5-methoxybiphenyl + H⁺

S-adenosyl-L-methionine + N-acetyl-N6,N6,O-tridemethylpuromycin → S-adenosyl-L-homocysteine + H⁺ + N-acetyl-N6,O-didemethylpuromycin

S-adenosyl-L-methionine + norajmaline → S-adenosyl-L-homocysteine + N_β-methylnorajmaline

S-adenosyl-L-methionine + 3,7,4'-trimethylquercetin → S-adenosyl-L-homocysteine + H⁺ + 3,7,3',4'-tetramethylquercetin

myricetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 3-O-methylmyricetin

S-adenosyl-L-methionine + cob(I)alamin → S-adenosyl-L-homocysteine + methylcob(III)alamin

S-adenosyl-L-methionine + 3,20-dimethyl-1,2,21,22-tetradehydro-2,3,20,21-tetrahydrobotryococcene → S-adenosyl-L-homocysteine + C33 botryococcene + H⁺

S-adenosyl-L-methionine + 2'-hydroxy 3,6,7,4'-tetramethylquercetagetin → S-adenosyl-L-homocysteine + H⁺ + 3,6,7,2',4'-pentamethylquercetagetin

myricetin + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 7-O-methylmyricetin

S-adenosyl-L-methionine + 2-methoxy-6-all trans-hexaprenyl-1,4-benzoquinol → S-adenosyl-L-homocysteine + H⁺ + 6-methoxy-3-methyl-2-all-trans-hexaprenyl-1,4-benzoquinol

desmethylxanthohumol + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + xanthohumol + H⁺

S-adenosyl-L-methionine + m7G(5')pppAm → S-adenosyl-L-homocysteine + m7G(5')pppm6Am + H⁺

S-adenosyl-L-methionine + esculetin → S-adenosyl-L-homocysteine + H⁺ + isoscopoletin

S-adenosyl-L-methionine + kaempferol → S-adenosyl-L-homocysteine + 3-O-methylkaempferol

S-adenosyl-L-methionine + cobalt-precorrin-4 → S-adenosyl-L-homocysteine + cobalt-precorrin-5A

S-adenosyl-L-methionine + (R)-noradrenaline → S-adenosyl-L-homocysteine + H⁺ + normetanephrine

S-adenosyl-L-methionine + putrescine → N-methylputrescine + S-adenosyl-L-homocysteine + H⁺

3,4-dihydroxy-5-all-trans-heptaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-heptaprenylbenzoate

S-adenosyl-L-methionine + demethylmenaquinol-8 → S-adenosyl-L-homocysteine + menaquinol-8 + H⁺

S-adenosyl-L-methionine + 3-demethylubiquinol-7 → S-adenosyl-L-homocysteine + H⁺ + ubiquinol-7

S-adenosyl-L-methionine + 3-O-acetyl-4'-O-demethylpapaveroxine → S-adenosyl-L-homocysteine + H⁺ + 3-O-aceylpapaveroxine

S-adenosyl-L-methionine + precorrin-7 → 2 H⁺ + S-adenosyl-L-homocysteine + precorrin-8x

S-adenosyl-L-methionine + TRIBOA-β-D-glucoside → S-adenosyl-L-homocysteine + H⁺ + DIMBOA-β-D-glucoside

S-adenosyl-L-methionine + gibberellin A₉ → S-adenosyl-L-homocysteine + methyl gibberellin A₉

S-adenosyl-L-methionine + desoxyhemigossypol → S-adenosyl-L-homocysteine + H⁺ + desoxyhemigossypol-6-methyl ether

6-O-methylnorlaudanosoline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + (S)-norreticuline

S-adenosyl-L-methionine + rhamnosyl tetracyclic spinosyn pseudoaglycone → S-adenosyl-L-homocysteine + 2'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone + H⁺

S-adenosyl-L-methionine + nocamycin E → S-adenosyl-L-homocysteine + nocamycin I

S-adenosyl-L-methionine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide d → S-adenosyl-L-homocysteine + (3¹R)-8-ethyl-12-methylbacteriochlorophyllide c + H⁺

S-adenosyl-L-methionine + norbixin → bixin + S-adenosyl-L-homocysteine

4-amino-4-de(dimethylamino)anhydrotetracycline + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + 4-methylamino-4-de(dimethylamino)anhydrotetracycline + H⁺

S-adenosyl-L-methionine + 6-demethylmitomycin B → S-adenosyl-L-homocysteine + mitomycin B

3,4-dihydroxy-5-all-trans-nonaprenylbenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-methoxy-4-hydroxy-5-all-trans-nonaprenylbenzoate

oleate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + dihydrosterculate

S-adenosyl-L-methionine + tetracenomycin B3 → S-adenosyl-L-homocysteine + tetracenomycin B2

gentamicin A2 + S-adenosyl-L-methionine → Gentamicin A2e + S-adenosyl-L-homocysteine

Gentamicin DAA2 + S-adenosyl-L-methionine → Gentamicin A-2 + S-adenosyl-L-homocysteine

Gentamicin DAA2 + S-adenosyl-L-methionine → gentamicin A + S-adenosyl-L-homocysteine

Gentamicin DAA2 + S-adenosyl-L-methionine → Gentamicin A-1 + S-adenosyl-L-homocysteine

gentamicin A + S-adenosyl-L-methionine → gentamicin Ae + S-adenosyl-L-homocysteine

Gentamicin A-2 + S-adenosyl-L-methionine → gentamicin Ae + S-adenosyl-L-homocysteine

Gentamicin A-2 + S-adenosyl-L-methionine → gentamicin X2-1 + S-adenosyl-L-homocysteine

gentamicin Ae + S-adenosyl-L-methionine → G-418 + S-adenosyl-L-homocysteine

bis-noryangonin + 2 S-adenosyl-L-methionine → yangonin + 2 S-adenosyl-L-homocysteine + H⁺

(E)-5,6-dihydro-4-hydroxy-6-(styryl)pyran-2-one + S-adenosyl-L-methionine → (R)-(+)-kavain + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + protostreptovaricin I → S-adenosyl-L-homocysteine + protostreptovaricin II + H⁺

pyridoxine + S-adenosyl-L-methionine → ginkgotoxin + S-adenosyl-L-homocysteine + H⁺

S-adenosyl-L-methionine + prostreptovaricin → S-adenosyl-L-homocysteine + 3-methylprostreptovaricin + H⁺

3-all trans-hexaprenyl-4,5-dihydroxybenzoate + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + H⁺ + 3-all trans-hexaprenyl-4-hydroxy-5-methoxybenzoate

S-adenosyl-L-methionine + 2',3'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone → S-adenosyl-L-homocysteine + 2',3',4'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone + H⁺

S-adenosyl-L-methionine + demethyldeoxyspectinabilin → S-adenosyl-L-homocysteine + deoxyspectinabilin + H⁺

2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine → 2-hexaprenyl-6-methoxy-3-methyl-1,4-benzoquinone + H+ + S-adenosyl-L-homocysteine

2-(3-Carboxy-3-aminopropyl)-L-histidine + S-adenosyl-L-methionine → 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine + H+ + S-adenosyl-L-homocysteine

3-demethylubiquinone-6 + H+ + S-adenosyl-L-methionine → S-adenosyl-L-homocysteine + ubiquinol-6

S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine → H+ + S-adenosyl-L-homocysteine + a phosphatidylcholine

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine → H+ + S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine

S-adenosyl-L-methionine + phosphatidylethanolamine → H+ + S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine

L-histidine + S-adenosyl-L-methionine → H+ + Nπ-methyl-L-histidine + S-adenosyl-L-homocysteine

serotonin + (R)-S-adenosyl-L-methionine → N-Methylserotonin + H⁺ + S-adenosyl-L-homocysteine

3 S-adenosyl-L-methionine + L-histidine → 3 S-adenosyl-L-homocysteine + 3 H⁺ + hercynine

Reversible reaction (9)

C31-phthiotriol + S-adenosyl-L-methionine ↔ S-adenosyl-L-homocysteine + C32-phthiocerol A + H⁺

2 S-adenosyl-L-methionine + uroporphyrin III ↔ 2 S-adenosyl-L-homocysteine + sirohydrochlorin

S-adenosyl-L-methionine + uroporphyrinogen-III ↔ S-adenosyl-L-homocysteine + precorrin-1 + H⁺

S-adenosyl-L-methionine + indol-3-ylmethylcarbamodithiolate ↔ S-adenosyl-L-homocysteine + H⁺ + brassinin

S-ribosyl-L-homocysteine + adenine ↔ H₂O + S-adenosyl-L-homocysteine

S-adenosyl-L-methionine + L-glutamine ↔ S-adenosyl-L-homocysteine + H⁺ + N⁵-methyl-L-glutamine

(S)-reticuline + S-adenosyl-L-methionine ↔ S-adenosyl-L-homocysteine + (S)-tembetarine + H⁺

S-adenosyl-L-methionine + 2-demethylmenaquinone-7 ↔ menaquinone-7 + S-adenosyl-L-homocysteine + H⁺

7-deoxyloganate + S-adenosyl-L-methionine ↔ 7-deoxyloganin + S-adenosyl-L-homocysteine

Compound as reactive (2)

Compound as product (570)

Reversible reaction (9)