Compound as reactive (1)
(2
R
,3
S
)-3-isopropylmalate
+ NAD
+
→ NADH + 4-methyl-2-oxopentanoate + CO
2
Compound as product (2)
3-methyl-2-oxobutanoate + acetyl-CoA + H2O →
(2R,3S)-3-isopropylmalate
+ coenzyme A + H+
3-methyl-2-oxobutanoate + acetyl-CoA + H2O → coenzyme A + H+ +
(2R,3S)-3-isopropylmalate
Reversible reaction (3)
(2
R
,3
S
)-3-isopropylmalate
↔ H
2
O + 2-isopropylmaleate
(2
R
,3
S
)-3-isopropylmalate
+ NAD
+
↔ (2
S
)-2-isopropyl-3-oxosuccinate + NADH + H
+
(2
R
,3
S
)-3-isopropylmalate
↔ (2
S
)-2-isopropylmalate