Compound as reactive (8)
H
2
O +
3-methyl-2-oxobutanoate
+ 5,10-methylenetetrahydropteroyl mono-L-glutamate → 2-dehydropantoate + 5,6,7,8-tetrahydrofolate
coenzyme A + an oxidized ferredoxin [iron-sulfur] cluster +
3-methyl-2-oxobutanoate
→ a reduced ferredoxin [iron-sulfur] cluster + H
+
+ isobutanoyl-CoA + CO
2
coenzyme A +
3-methyl-2-oxobutanoate
+ NAD
+
→ NADH + isobutanoyl-CoA + CO
2
3-methyl-2-oxobutanoate
+ H
+
→ isobutanal + CO
2
H
2
O + 5,10-methylene-tetrahydromethanopterin +
3-methyl-2-oxobutanoate
→ tetrahydromethanopterin + 2-dehydropantoate
H
2
O +
3-methyl-2-oxobutanoate
+ acetyl-CoA → coenzyme A + (2
S
)-2-isopropylmalate + H
+
3-methyl-2-oxobutanoate
+ acetyl-CoA + H2O → (2R,3S)-3-isopropylmalate + coenzyme A + H+
3-methyl-2-oxobutanoate
+ acetyl-CoA + H2O → coenzyme A + H+ + (2R,3S)-3-isopropylmalate
Compound as product (2)
3-methyl-2-oxobutanoate
← 2-oxovalerate
(2
R
)-2,3-dihydroxy-3-methylbutanoate → H
2
O +
3-methyl-2-oxobutanoate
Reversible reaction (7)
pyruvate + L-valine ↔
3-methyl-2-oxobutanoate
+ L-alanine
2-dehydropantoate ↔
3-methyl-2-oxobutanoate
+ formaldehyde
H
2
O + NADP
+
+ L-valine ↔ NADPH +
3-methyl-2-oxobutanoate
+ H
+
+ ammonium
2-oxoglutarate + L-valine ↔
3-methyl-2-oxobutanoate
+ L-glutamate
H
2
O + NAD
+
+ L-valine ↔ NADH +
3-methyl-2-oxobutanoate
+ H
+
+ ammonium
NAD
+
+ (
R
)-3,3-dimethylmalate ↔ NADH +
3-methyl-2-oxobutanoate
+ CO
2
(
S
)-3-methyl-2-oxopentanoate + L-valine ↔
3-methyl-2-oxobutanoate
+ L-isoleucine