Compound as reactive (2)
H
2
O +
5,10-methenyltetrahydrofolate mono-L-glutamate
→ H
+
+ (6
S
)-5-formyl-tetrahydrofolate mono-L-glutamate
5,10-methenyltetrahydrofolate mono-L-glutamate
+ N1-(5-phospho-β-D-ribosyl)glycinamide + H2O → N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + 2 H+ + 5,6,7,8-tetrahydrofolate
Compound as product (2)
2 H
+
+ 5-formiminotetrahydrofolate → ammonium +
5,10-methenyltetrahydrofolate mono-L-glutamate
NAD
+
+ 5,10-methylenetetrahydropteroyl mono-L-glutamate → NADH +
5,10-methenyltetrahydrofolate mono-L-glutamate
Reversible reaction (4)
H
2
O +
5,10-methenyltetrahydrofolate mono-L-glutamate
↔ 10-formyl-tetrahydrofolate mono-L-glutamate + H
+
NADP
+
+ 5,10-methylenetetrahydropteroyl mono-L-glutamate ↔ NADPH +
5,10-methenyltetrahydrofolate mono-L-glutamate
(6
S
)-5-formyl-tetrahydrofolate mono-L-glutamate + ATP ↔ phosphate +
5,10-methenyltetrahydrofolate mono-L-glutamate
+ ADP
an oxidized electron donor + 5-methyltetrahydropteroyl mono-L-glutamate ↔ a reduced electron donor +
5,10-methenyltetrahydrofolate mono-L-glutamate