an oxidized electron donor

a reduced electron donor

a deaminated amino group acceptor

an aminated amino group acceptor

Charged-LEU-tRNAs

LEU-tRNAs

a 2-oxo acid

an amino acid

an acyl-CoA

a carboxylate

an oxidized ferredoxin [iron-sulfur] cluster

a reduced ferredoxin [iron-sulfur] cluster

NAD(P)H

NAD(P)+

an L-tyrosyl-[tRNAtyr]

a tRNAtyr

(2Z,4Z)-2-hydroxy-5-carboxymuconate-6-semialdehyde

4α,14α-dimethyl-porifersta-8,25(27)-dienol

2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate

4-methylcyclohex-1,5-diene-1-carbonyl-CoA

isoshowacene

2-hydroxyhexadecanal

16-sinapoyloxypalmitate

3-methylquinolin-2-ol

(22R)-hydroxycholesterol

N-(2-methylpropyl)hydroxylamine

chloroeremomycin

3-hydroxy-3-methylbutanoate

2',3',4'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone

2',3'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone

2'-O-methyl-rhamnosyl tetracyclic spinosyn pseudoaglycone

rhamnosyl tetracyclic spinosyn pseudoaglycone

rhamnosyl tricyclic spinosyn pseudoaglycone

spinosyn tricyclic macrolactone

11-dehydro-15-oxo spinosyn macrolactone

15-oxo spinosyn macrolactone

spinosyn macrolactone

diethylamine N-oxide

triethylamine N-oxide

UDP-2-acetamido-2-deoxy-α-D-ribo-hex-3-uluronate

nitroxyl

trans,octacis-decaprenylphospho-β-D-arabinofuranose

1,3-dihydro-2H-imidazol-2-one

2-phenylethyl β-D-glucopyranoside

formyl hopane

ribosyl hopane

adenosyl hopane

(2Z)-2-hydroxypenta-2,4-dienoate

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate

(2Z)-2,4-dihydroxypent-2-enoate

(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA

(3R,5Z,8Z,11Z,14Z,17Z)-3-hydroxydocosapentaenoyl-CoA

(5Z,8Z,11Z,14Z,17Z)-3-oxodocosapentaenoyl-CoA

(+)-3'-hydroxylarreatricin

(+)-larreatricin

2-trans,4-trans-xanthoxin

(2R,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one

1,2-dihydro-β-NADP

(2S,4S)-2-methyl-2,4-dihydroxydihydrofuran-3-one

enol-phenylpyruvate

ammonia

(2E)-2-hydroxypenta-2,4-dienoate

(3E)-2-oxopent-3-enoate

(2S,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran

(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran

(E)-4-coumaroyl-CoA

3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA

2,3-didehydroadipyl-CoA

CO₂

5-amino-6-(D-ribitylamino)uracil

shikimate

(S)-2-acetolactate

(S)-2-aceto-2-hydroxybutanoate

S-adenosyl 3-(methylsulfanyl)propylamine

(R)-mandelate

(S)-mandelate

5-dehydro-4-deoxy-D-glucarate

3-dehydroshikimate

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate

H₂O

oxaloacetate

(S)-1-phenylethanol

urea

N²-formyl-N¹-(5-phospho-β-D-ribosyl)glycinamide

N¹-(5-phospho-β-D-ribosyl)glycinamide

7-carboxy-7-deazaguanine

selenophosphate

glycolate

2-phosphoglycolate

chlorite

nicotinate adenine dinucleotide

(S)-3-methyl-2-oxopentanoate

(R)-2,3-dihydroxy-3-methylpentanoate

3-methyl-2-oxobutanoate

5-oxo-L-proline

oxalosuccinate

S-methyl-5-thio-α-D-ribose 1-phosphate

S-methyl-5'-thioadenosine

isopentenyl diphosphate

L-canavanine

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine

4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine

2-dehydropantoate

2-isopropylmaleate

(2R,3S)-3-isopropylmalate

(2S)-2-isopropylmalate

acetoacetate

phosphoenolpyruvate

1-deoxy-L-glycero-tetrulose 4-phosphate

(2E)-2-methyl-4,6-dioxohept-2-enedioate

3-methylgentisate

(2E)-3-methyl-4,6-dioxohept-2-enedioate

4-methylgentisate

3-maleylpyruvate

4,5-dihydroxyphthalate

(S)-4-hydroxy-2-oxopentanoate

2-oxopent-4-enoate

2-hydroxy-5-carboxymethylmuconate semialdehyde

(4S)-4-hydroxy-2-oxoheptanedioate

(4Z)-2-oxohept-4-enedioate

3-oxopropanoate

coenzyme F₃₉₀-A

adenosine 5'-phosphoselenate

adenosine 5'-phosphosulfate

coproporphyrinogen III

(4-hydroxyphenyl)acetate

5-amino-1-(5-phospho-β-D-ribosyl)imidazole

2-(formamido)-N¹-(5-phospho-β-D-ribosyl)acetamidine

3-hydroxypropanoate

3-phosphooxypyruvate

(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate

2-maleylacetate

α-D-ribose 1,5-bisphosphate

hydrogenobyrinate a,c-diamide

hydrogenobyrinate

5-amino-6-(5-phospho-D-ribosylamino)uracil

5-amino-6-(5-phospho-D-ribitylamino)uracil

carbon monoxide

5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole

prephenate

2-oxovalerate

3-ethylmalate

4-methyl-2-oxopentanoate

(2S)-2-isopropyl-3-oxosuccinate

acetyl phosphate

2'-(5''-triphospho-α-D-ribosyl)-3'-dephospho-CoA

4'-phosphopantetheine

(R)-4'-phosphopantothenoyl-L-cysteine

preuroporphyrinogen

porphobilinogen

5-aminolevulinate

(S)-4-amino-5-oxopentanoate

α-ribazole 5'-phosphate

α-ribazole

N-acetylglutamyl-phosphate

N-acetyl-L-glutamate 5-semialdehyde

succinate semialdehyde

4-aminobutanoate

citrate

glycerone phosphate

carbonic acid

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate

isochorismate

FK-506

31-O-desmethylFK-506

3-deoxy-D-arabino-heptulosonate 7-phosphate

3-dehydroquinate

5-enolpyruvoyl-shikimate 3-phosphate

shikimate 3-phosphate

hydrogen peroxide

L-histidinol phosphate

imidazole acetol-phosphate

D-erythro-imidazole-glycerol-phosphate

histidinol

histidinal

(S)-dihydroorotate

carbamoyl phosphate

orotidine 5'-phosphate

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

5-phospho-β-D-ribosylamine

L-arginino-succinate

canavaninosuccinate

O-ureido-L-homoserine

carboxyphosphate

N-ethylammeline

deethylsimazine

2,6-dioxo-6-phenylhexa-3-enoate

3-(O-geranylgeranyl)-sn-glycerol 1-phosphate

prenyl diphosphate

4-prenylphlorisobutyrophenone

(2Z,4Z)-2-hydroxyhepta-2,4-dienedioate

anthranilate

N-(5-phosphoribosyl)-anthranilate

(R)-mevalonate

β-nicotinate D-ribonucleotide

4-(β-D-ribofuranosyl)hydroxybenzene 5'-phosphate

(R)-5-phosphomevalonate

(indol-3 yl)acetyl-CoA

(indol-3-yl)pyruvate

(R)-mevalonate diphosphate

dihydromethanophenazine

CoB-CoM heterodisulfide

methanophenazine

coenzyme B

N⁵-carboxyaminoimidazole ribonucleotide

(4,5-dihydro-5-oxofuran-2-yl)-acetate

muconolactone

4-methyl-3-oxoadipate-enol-lactone

3-methylmuconolactone

dialurate

5,6-dimethylbenzimidazole

(R)-1-amino-2-propanol O-2-phosphate

(R)-4'-phosphopantothenate

(R)-4-phosphopantoate

autoinducer 2

S-ribosyl-L-homocysteine

L-cysteinylglycine

hypoglycin B

carbamate

L-citrulline

L-methionine

L-leucine

L-glutamate

L-glutamine

L-arginine

L-tryptophan

L-serine

L-proline

glycine

L-aspartate

L-threonine

L-histidine

L-phenylalanine

L-tyrosine

L-valine

L-glutamate-5-semialdehyde

L-homocysteine

S-adenosyl-L-methionine

L-aspartate 4-semialdehyde

L-canaline

L-ornithine

O-phospho-L-homoserine

L-homoserine

S-adenosyl-L-homocysteine

hypoglycin A

L-selenomethionine

seleno-L-homocysteine

L-aspartyl-4-phosphate

trans-4-hydroxy-L-proline

N-acetyl-L-citrulline

N-acetyl-L-ornithine

N-acetyl-L-glutamate

N-carbamoyl-L-aspartate

3-phospho-L-serine

β-alanine

protocatechuate

benzoate

acetate

5-chloro-5-deoxy-D-ribonate

gentisate

orotate

(R)-pantoate

(S)-1-pyrroline-5-carboxylate

pristanate

palmitate

stearate

decanoate

laurate

7-hydroxylaurate

octanoate

18-hydroxyoleate

16-hydroxypalmitate

18-hydroxystearate

linoleate

α-linolenate

oleate

(15Z)-tetracosenoate

phytenate

(2R,3S)-2-methylisocitrate

3-phenyl-2-oxopropanoate

pyruvate

2-oxobutanoate

5-chloro-4-hydroxy-2-oxopentanoate

2-oxoglutarate

cis-homoaconitate

(2R)-homocitrate

cis-aconitate

D-threo-isocitrate

chorismate

D-galactarate

α,ω-9Z-octadecenedioate

succinate

fumarate

(S)-malate

formate

propanoate

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

5-formamido-1-(5-phospho-D-ribosyl)-imidazole-4-carboxamide

phosphoribulosylformimino-AICAR-phosphate

1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide

phlorisovalerophenone

3-benzyl-3,6 -bis(cysteinylglycine)- 6-(hydroxymethyl)-diketopiperazine

3-benzyl-3,6 -bis(glutathione)- 6-(hydroxymethyl)-diketopiperazine

daunorubicin

(2E,6E)-farnesyl diphosphate

geranyl diphosphate

4-prenylphlorisovalerophenone

deoxycohumulone

deoxyhumulone

geranylgeranyl diphosphate

dTDP-4-dehydro-6-deoxy-α-D-glucopyranose

ADP-D-ribose

ADP ribose 1''-phosphate

ADP ribose 1'',2''-cyclic phosphate

GDP-α-D-mannose

2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

dTDP-4-dehydro-β-L-rhamnose

dTDP-β-L-rhamnose

dTDP-α-D-glucose

UDP-α-D-glucuronate

UDP-α-D-glucose

5-phospho-α-D-ribose 1-diphosphate

D-sedoheptulose 7-phosphate

D-erythrose 4-phosphate

1-(o-carboxyphenylamino)-1'-deoxyribulose 5'-phosphate

β-D-fructofuranose 1-phosphate

β-D-glucopyranose 1-phosphate

α-D-glucopyranose 1-phosphate

D-fructose 6-phosphate

β-D-fructofuranose 6-phosphate

β-D-fructose 1,6-bisphosphate

β-D-glucose 6-phosphate

D-xylulose 5-phosphate

D-ribulose 5-phosphate

aldehydo-D-ribose 5-phosphate

β-D-ribose 5-phosphate

α-D-ribose 5-phosphate

D-ribulose-1,5-bisphosphate

D-glyceraldehyde 3-phosphate

β-D-fructofuranose

β-D-galactopyranose

α-D-galactopyranose

β-D-glucopyranose

α-D-glucopyranose

D-glyceraldehyde

α-D-ribofuranose

3,4-dihydroxyphenylacetate

1D-myo-inositol 3-monophosphate

caldariellaquinone

acetone

4-hydroxybenzoate

ethylbenzene

caldariellaquinol

indole

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate

adenine

AMP

IMP

GMP

XMP

ATP

GTP

ITP

ADP

GDP

IDP

dADP

dGDP

dIDP

dATP

dGTP

dITP

adenosine

(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin

tetrahydromethanopterin

7,8-dihydroneopterin 3'-triphosphate

5,10-methylene-tetrahydromethanopterin

tetrahydropteroyl tri-L-glutamate

5-methyltetrahydropteroyl tri-L-glutamate

guanylyl molybdenum cofactor

MoO₂-molybdopterin cofactor

FMNH₂

FADH₂

reduced riboflavin

riboflavin

FMN

FAD

6,7-dimethyl-8-(1-D-ribityl)lumazine

uracil

CTP

dTDP

dTMP

UTP

UDP

dCTP

dCDP

CDP

dUTP

dUDP

dTTP

dCMP

dUMP

CMP

UMP

uridine

cytidine

2'-deoxyuridine

2'-deoxycytidine

cob(I)alamin

adenosylcobalamin

sirohydrochlorin

cobyrinate

cobalt-precorrin-2

precorrin-2

precorrin-1

precorrin-8x

precorrin-7

precorrin-6B

precorrin-4

precorrin-3B

precorrin-3A

precorrin-5

coenzyme A

coenzyme M

oxidized coenzyme F₄₂₀-2

5'-deoxyadenosine

adenylo-succinate

cyclic-AMP

1-(5-phospho-β-D-ribosyl)-ATP

1-(5-phospho-β-D-ribosyl)-AMP

β-nicotinamide D-ribonucleotide

cyclic di-3',5'-guanylate

NAD⁺

NADP⁺

NADPH

NADH

(S)-NADHX

(R)-NADHX

nicotinate

phenylacetate

(indol-3-yl)acetate

(25S)-3-oxocholest-4-en-26-oyl-CoA

(25S)-3-oxocholest-4-en-26-oate

trans-dienelactone

cis-dienelactone

methylacrylyl-CoA

3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(E-hexa-2-enoyl)-CoA

3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxyhexanoyl)-CoA

(E)-2-methylcrotonoyl-CoA

3-hydroxyisovaleryl-CoA

3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(E-octa-2-enoyl)-CoA

3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxyoctanoyl)-CoA

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA

(3S)-hydroxyadipyl-CoA

3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(E-buta-2-enoyl)-CoA

3-oxo-2-(cis-2'-pentenyl)-cyclopentane-1-(3R-hydroxybutanoyl)-CoA

isobutanoyl-CoA

linoleoyl-CoA

α-linolenoyl-CoA

phenylacetyl-CoA

acetyl-CoA

2-methylacetoacetyl-CoA

4-hydroxybenzoyl-CoA

(3S)-citryl-CoA

succinyl-CoA

3-hydroxypropanoyl-CoA

4-hydroxybutanoyl-CoA

3'-dephospho-CoA

malonyl-CoA

CoA-disulfide

(S)-3-hydroxy-3-methylglutaryl-CoA

(S)-3-hydroxy-isobutanoyl-CoA

phytenoyl-CoA

crotonyl-CoA

(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA

(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA

(2E)-oct-2-enoyl-CoA

(2E)-dec-2-enoyl-CoA

(R)-methylmalonyl-CoA

(S)-methylmalonyl-CoA

ω-carboxy-(9Z)-octadec-9-enoyl-CoA

oleoyl-CoA

16-hydroxypalmitoyl-CoA

18-hydroxyoleoyl-CoA

18-hydroxystearoyl-CoA

palmitoyl-CoA

stearoyl-CoA

decanoyl-CoA

lauroyl-CoA

7-hydroxylauroyl-CoA

octanoyl-CoA

propanoyl-CoA

(Z)-15-tetracosenoyl-CoA

(3R)-3-hydroxybutanoyl-CoA

(S)-3-hydroxybutanoyl-CoA

(3S,6Z,9Z,12Z,15Z,18Z)-3-hydroxytetracosapentaenoyl-CoA

(3S,6Z,9Z,12Z,15Z,18Z,21Z)-3-hydroxytetracosahexaenoyl-CoA

(S)-3-hydroxyoctanoyl-CoA

(S)-3-hydroxydecanoyl-CoA

pristanoyl-CoA

3-oxopentanoyl-CoA

acetoacetyl-CoA

glutathione

3-sulfopyruvate

L-cysteate

thiocyanate

agmatine

putrescine

spermidine

dehydrospermidine

N-acetylputrescine

(2Z)-2-aminobut-2-enoate

superoxide

2-chloroacetate

(R)-4-hydroxymandelate

(S)-4-hydroxymandelate

(R)-methylmalonate-semialdehyde

(S)-methylmalonate-semialdehyde

(2R)-2,3-dihydroxy-3-methylbutanoate

ω-saturated C55 dolichol phosphate

3-phospho-D-glyceroyl-phosphate

3-phospho-D-glycerate

2-phospho-D-glycerate

sn-glycerol 1-phosphate

β-D-mannosyl-(C55 ω-saturated dolichyl phosphate)

oxygen

Hg⁰

uroporphyrinogen-I

protoporphyrinogen IX

uroporphyrinogen-III

siroheme

adenosylcobinamide-GDP

adenosyl-cobinamide phosphate

cob(II)yrinate a,c-diamide

cob(I)yrinate a,c-diamide

cobalt-sirohydrochlorin

cob(II)yrinate c-monoamide

adenosylcobyrate

adenosyl-cob(III)yrinate a,c-diamide

adenosylcobalamin 5'-phosphate

adenosylcobinamide

cob(I)inamide

hydrogensulfite

sulfate

selenide

hydrogencarbonate

sulfite

selenate

thiosulfate

nitrate

molybdate

chloride

phosphate

diphosphate

triphosphate

Hg²⁺

Co²⁺

Cd²⁺

Pb²⁺

Zn²⁺

Fe²⁺

ammonium

H⁺

K⁺

Na⁺

2-iminobutanoate

(S)-3-hydroxy-isobutanoate

hydrogen cyanide

(indole-3-yl)acetonitrile

preQ₀