Escherichia coli HS19

Ancestors

All strains

Escherichia coli K12

Escherichia coli W1485

Escherichia coli W2637

Escherichia coli W3110

Escherichia coli HS

Escherichia coli HS7

Escherichia coli HS8

Escherichia coli HS13

Escherichia coli HS19

Derived strains

Genotype with respect to parental

P_trc::P_asd

Genotype with respect to wild type

F⁺ (λ) | λ- | inv(rrnD-rrnE) | F-, λ-, rph-1, IN (rrnD, rrnE) | ΔJIB* ΔthrB ΔmetA ΔlysA ΔiclR ΔptsG ΔgalR ΔlacI::Ptrc-rhtA Ptrc-rhtA Ptrc-eamA Ptrc-metL Ptrc-thrA Ptrc-glk Ptrc-gltB | Δadd Δamn | P_trc-ado1_Sc | Δyjit::P_trc-thrA^fbr | P_trc::P_asd

Bars (|) indicate differences between strains.

Modifications

Gene	Organism	Modification
asd	Escherichia coli	Overexpression

Production

Metabolites	Heterologous	Production type	Production	Biomass	Carbon source	Time	Scale	Ref.
L-homoserine		Titer	16.87 g/L ^*	14.07 OD₆₀₀^*	Glucose		Flask	[ 255 ]

* Inferred from plots using RetroPlot.

References

Niu, Kun; Zheng, Rui; Zhang, Miao; Chen, Mao‐Qin; Kong, Yi‐Ming; Liu, Zhi‐Qiang & Zheng, Yu‐Guo. Adjustment of the main biosynthesis modules to enhance the production of l‐homoserine in Escherichia coli W3110. Biotechnology and Bioengineering. 2024.