Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications
Titer in Flask for L-(-)-3-Phenyllactic acid
Modifications | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Strain | Maximum production | tyrA | tyrB | ppr | trpE | ptsH | ptsI | crr | glf | glk | aroG | pheA | tktA | pck | ghrB | pprA | ldhL | fdh |
E. coli CGSC4510 | 28 mg/L | |||||||||||||||||
E. coli MG-P2 | 189 mg/L | |||||||||||||||||
E. coli MG-P3 | 212 mg/L | |||||||||||||||||
E. coli MG-P1 | 251 mg/L | |||||||||||||||||
E. coli MG-P4 | 417 mg/L | |||||||||||||||||
E. coli MP-P5 | 578 mg/L | |||||||||||||||||
E. coli MG-P6 | 717.4 mg/L | |||||||||||||||||
E. coli MG-P7 | 880 mg/L | |||||||||||||||||
E. coli MG-P8 | 1,140 mg/L | |||||||||||||||||
E. coli MG-P9 | 1,210 mg/L | |||||||||||||||||
E. coli MG-P10 | 1,420 mg/L | |||||||||||||||||
E. coli BL21(pETDuet-ldhL-fdh) | 13,227.132 mg/L |
Titer in Fed-Batch for L-(-)-3-Phenyllactic acid
Modifications | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Strain | Maximum production | tyrA | tyrB | ppr | trpE | ptsH | ptsI | crr | glf | glk | aroG | pheA | tktA | pck |
E. coli MG-P10 | 52,890 mg/L |
Substrate yield in Fed-Batch for L-(-)-3-Phenyllactic acid
Modifications | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Strain | Maximum production | tyrA | tyrB | ppr | trpE | ptsH | ptsI | crr | glf | glk | aroG | pheA | tktA | pck |
E. coli MG-P10 | 0.225 g/g of sustrate |
Substrate yield in Flask for L-(-)-3-Phenyllactic acid
Modifications | |||
---|---|---|---|
Strain | Maximum production | ldhL | fdh |
E. coli BL21(pETDuet-ldhL-fdh) | 0.961 g/g of sustrate |
Volumetric productivity in Fed-Batch for L-(-)-3-Phenyllactic acid
Modifications | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Strain | Maximum production | tyrA | tyrB | ppr | trpE | ptsH | ptsI | crr | glf | glk | aroG | pheA | tktA | pck |
E. coli MG-P10 | 1,102 mg/L/h |