Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for itaconate

Modifications
Strain Maximum production aceA sucC sucD pykA pykF pta icd cadA gltA
E. coli ita6 20 mg/L
E. coli ita12 20 mg/L
E. coli ita19 60 mg/L
E. coli ita1 110 mg/L
E. coli ita4 110 mg/L
E. coli ita23 2,270 mg/L

Titer in Fed-Batch for itaconate

Modifications
Strain Maximum production aceA sucC sucD pykA pykF pta icd cadA gltA
E. coli ita23 32,000 mg/L

Substrate yield in Flask for itaconate

Modifications
Strain Maximum production aceA sucC sucD pykA pykF pta icd cadA gltA
E. coli ita12 0.00427 g/g of sustrate
E. coli ita6 0.00498 g/g of sustrate
E. coli ita19 0.01422 g/g of sustrate
E. coli ita4 0.02559 g/g of sustrate
E. coli ita1 0.02773 g/g of sustrate
E. coli ita23 0.5453 g/g of sustrate

Substrate yield in Fed-Batch for itaconate

Modifications
Strain Maximum production aceA sucC sucD pykA pykF pta icd cadA gltA
E. coli ita23 0.48345 g/g of sustrate

Volumetric productivity in Fed-Batch for itaconate

Modifications
Strain Maximum production aceA sucC sucD pykA pykF pta icd cadA gltA
E. coli ita23 450 mg/L/h