Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for uridine

Modifications
Strain Maximum production lacIEc pyrBBs pyrCBs pyrAABs pyrABBs pyrKBs pyrDBs pyrFBs pyrEBs udkEc udpEc rihAEc rihBEc rihCEc tyrREc argFEc ppcEc thrAEc iclREc purREc trpREc prsAEc nupCEc nupGEc
E. coli W3110 0 mg/L
E. coli UR1 5,500 mg/L
E. coli UR2-5 7,800 mg/L
E. coli UR3-2 8,200 mg/L
E. coli UR3-1 9,300 mg/L
E. coli UR3-3 10,300 mg/L
E. coli UR4 12,300 mg/L
E. coli UR5-1 12,800 mg/L
E. coli UR5-2 13,800 mg/L
E. coli UR6 14,500 mg/L

Titer in Fed-Batch for uridine

Modifications
Strain Maximum production lacIEc pyrBBs pyrCBs pyrAABs pyrABBs pyrKBs pyrDBs pyrFBs pyrEBs udkEc udpEc rihAEc rihBEc rihCEc tyrREc argFEc ppcEc thrAEc iclREc purREc trpREc prsAEc nupCEc nupGEc
E. coli UR6 70,300 mg/L

Substrate yield in Flask for uridine

Modifications
Strain Maximum production lacIEc pyrBBs pyrCBs pyrAABs pyrABBs pyrKBs pyrDBs pyrFBs pyrEBs udkEc udpEc rihAEc rihBEc rihCEc tyrREc argFEc ppcEc thrAEc iclREc purREc trpREc prsAEc nupCEc nupGEc
E. coli UR2-5 0.057 g/g of sustrate
E. coli UR3-2 0.062 g/g of sustrate
E. coli UR3-1 0.073 g/g of sustrate
E. coli UR3-3 0.086 g/g of sustrate
E. coli UR4 0.107 g/g of sustrate
E. coli UR5-1 0.116 g/g of sustrate
E. coli UR5-2 0.157 g/g of sustrate
E. coli UR6 0.161 g/g of sustrate

Substrate yield in Fed-Batch for uridine

Modifications
Strain Maximum production lacIEc pyrBBs pyrCBs pyrAABs pyrABBs pyrKBs pyrDBs pyrFBs pyrEBs udkEc udpEc rihAEc rihBEc rihCEc tyrREc argFEc ppcEc thrAEc iclREc purREc trpREc prsAEc nupCEc nupGEc
E. coli UR6 0.259 g/g of sustrate

Volumetric productivity in Fed-Batch for uridine

Modifications
Strain Maximum production lacIEc pyrBBs pyrCBs pyrAABs pyrABBs pyrKBs pyrDBs pyrFBs pyrEBs udkEc udpEc rihAEc rihBEc rihCEc tyrREc argFEc ppcEc thrAEc iclREc purREc trpREc prsAEc nupCEc nupGEc
E. coli UR6 1,100 mg/L/h