Silencing
Overexpression
Feedback insensitive
Attenuation
Feed-forward insensitive
Inhibition insensitive
Unstated
Combined modifications

Titer in Flask for L-tyrosine

Modifications
Strain Maximum production tyrREc aroGEc tyrAEc ppsAEc tktAEc aroLEc tyrCZm tyrPEc aroPEc aroHEc tnaAEc tnaBEc pheAEc pheLEc trpEEc ydiBEc aroDEc aroBEc tyrBEc aroCEc aroAEc aroKEc aroEEc
E. coli K12 ΔtyrR 0 mg/L
E. coli BTY0.3 0 mg/L
E. coli BTY0.4 0 mg/L
E. coli K12 ΔtyrR (pCL1920::aroGWT tyrAWT) 6 mg/L
E. coli K12 ΔtyrR (pCL1920::aroGfbr tyrAWT) 71 mg/L
E. coli K12 ΔtyrR (pCL1920::aroGWT tyrAfbr) 86 mg/L
E. coli K12 ΔtyrR (pCL1920::aroGfbr tyrAfbr) 127 mg/L
E. coli DPD4193 180 mg/L
E. coli T1 346 mg/L
E. coli K12 ΔtyrR (pCL1920::PLtetO−1 aroGfbr tyrAfbr tktA) 380 mg/L
E. coli K12 ΔtyrR (pCL1920::PLtetO−1aroGfbr tyrAfbr ppsA) 466 mg/L
E. coli BTY0.5 488.4 mg/L
E. coli BTY1.5 552.6 mg/L
E. coli T2 621 mg/L
E. coli A (pS0, pY0) 746 mg/L
E. coli BTY0.10 760.6 mg/L
E. coli BTY1.2 806 mg/L
E. coli B (pS0, pY1) 897 mg/L
E. coli E (pS4, pY2) 908 mg/L
E. coli BTY0.11 923 mg/L
E. coli BTY1.10 942.6 mg/L
E. coli BTY1.1 1,083.6 mg/L
E. coli C (pS4, pY1) 1,150 mg/L
E. coli D (pS5, pY1) 1,219 mg/L
E. coli BTY1.11 1,235 mg/L
E. coli BTY1.12 1,239 mg/L
E. coli G (pS5, pY3) 1,310 mg/L
E. coli BTY0.12 1,808 mg/L
E. coli BTY1.13 1,896 mg/L
E. coli BTY0.13 2,004 mg/L
E. coli F (pS4, pY3) 2,169 mg/L
E. coli BTY7.13 2,483 mg/L
E. coli BTY2.13 2,567 mg/L

Titer in Fed-Batch for L-tyrosine

Modifications
Strain Maximum production tyrREc aroGEc tyrAEc ppsAEc tktAEc tyrPEc aroLEc tyrCZm aroPEc aroHEc tnaAEc tnaBEc pheAEc pheLEc trpEEc
E. coli T1 3,800 mg/L
E. coli T2 9,700 mg/L
E. coli BTY0.13 11,550 mg/L
E. coli BTY7.13 28,730 mg/L
E. coli BTY5.13 29,320 mg/L
E. coli BTY2.13 43,140 mg/L
E. coli DPD4193 55,000 mg/L

Substrate yield in Fed-Batch for L-tyrosine

Modifications
Strain Maximum production tyrREc aroGEc tyrAEc ppsAEc tktAEc
E. coli T1 0.037 g/g of sustrate
E. coli T2 0.102 g/g of sustrate

Substrate yield in Flask for L-tyrosine

Modifications
Strain Maximum production aroHEc tyrREc tnaAEc tnaBEc aroGEc tyrAEc pheAEc pheLEc trpEEc
E. coli DPD4193 0.09 g/g of sustrate

Biomass-specific yield in Flask for L-tyrosine

Modifications
Strain Maximum production ydiBEc aroDEc aroBEc aroGEc ppsAEc tktAEc tyrBEc tyrAEc aroCEc aroAEc aroKEc aroEEc aroLEc
E. coli A (pS0, pY0) 921 mg/g DCW
E. coli B (pS0, pY1) 944 mg/g DCW
E. coli E (pS4, pY2) 987 mg/g DCW
E. coli C (pS4, pY1) 1,307 mg/g DCW
E. coli D (pS5, pY1) 1,451 mg/g DCW
E. coli G (pS5, pY3) 1,617 mg/g DCW
E. coli F (pS4, pY3) 2,645 mg/g DCW